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TranscriptomicssRNA profiles of control adults, postdauer adults, larva L3, and dauer stages of C. elegans
Early environmental experiences and life histories profoundly influence adult phenotypes via as yet poorly understood mechanisms. We previously showed that wild-type adult C. elegans that transiently passed through the stress-induced dauer larval stage (post-dauers) exhibit different gene expression...
ORGANISM(S): Caenorhabditis elegans 
2013-04-05 | E-GEOD-33313 | biostudies-arrayexpress
TranscriptomicsCharacterization of the piRNA Complex from Rat Testes
This data series contains the sequences and read counts of Piwi-interacting RNAs and other small RNAs from mouse and rat testes extracts. In a search for different classes of small RNAs that might be involved in transcriptional gene silencing, we encountered a novel class of small RNAs within mamma...
ORGANISM(S): Mus musculus 
2006-07-02 | E-GEOD-5026 | biostudies-arrayexpress
TranscriptomicsDrosophila OSS cell small RNA libraries
High-throughput sequencing of Drosophila melanogaster small RNAs from OSS cells. total RNA, ~18-26nt RNAs isolated using PAGE, ligation to adapters requires 5' monophosphate and 3' OH For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Page...
ORGANISM(S): Drosophila melanogaster 
2009-06-08 | E-GEOD-15378 | biostudies-arrayexpress
ProteomicsTraffic jam directly regulates the Drosophila piRNA cluster flamenco and the Piwi pathway gene network to ensure transposon silencing and female fertility.
The flamenco (flam) locus is the most prominent piRNA cluster locus expressed in Drosophila ovarian follicle cells that is required for female fertility and silencing of gypsy/mdg4 transposons. Although P-element insertions in the flam promoter region disrupts flam piRNAs and cause female infertilit...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-01 | PXD052946 | Pride
Transcription Tmt Multiplexed proteomics Traffic jam Affinity enrichment Transposon Pirna Fertilitym transposon Drosophila melanogaster 
TranscriptomicsXenopus egg small RNA associated with Y12 antibody
We examined in Xenopus tropicalis eggs piRNAs that are associated with Y12 antibody, which binds symmetrically methylated arginines that are present on diverse Piwi proteins. The goal of this experiment is to more deeply characterize the piRNA pool from adult Xenopus extracts, using the Illumina pla...
ORGANISM(S): Xenopus (Silurana) tropicalis 
2010-01-04 | E-GEOD-19173 | biostudies-arrayexpress
TranscriptomicsMili-IP, Miwi-IP, and total RNA from mouse adult testis
We deep-sequenced small RNAs after immunoprecipitation of Mili or Miwi, as well as total small RNA from adult mouse testis. The goal of this experiment is to more deeply characterize the piRNA pool from adult mouse testes, using the Illumina platform. Comparison of 2 IP libraries with a non-IP libr...
ORGANISM(S): Mus musculus 
2010-01-04 | E-GEOD-19172 | biostudies-arrayexpress
TranscriptomicsAn mRNA/3' UTR-directed primary piRNA pathway in Drosophila ovarian somatic cells
Piwi-interacting RNAs (piRNAs) are ~24-30 nucleotide regulatory RNAs that are abundantly expressed in gonads. The most well-understood piRNAs mediate post-transcriptional defense against transposable elements (TEs), and derive from sense or antisense strands as a consequence of "ping-pong"...
ORGANISM(S): Drosophila melanogaster 
2010-01-03 | E-GEOD-15825 | biostudies-arrayexpress
UnknownIncorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.
Not available
S-EPMC5013254 | biostudies-literature
UnknownA Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.
Not available
S-EPMC5294886 | biostudies-literature
UnknownDe Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects.
Not available
S-EPMC6817525 | biostudies-literature
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