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ProteomicsLocus-specific proteomics identifies CHD4 and Polycomb PRC1 as novel repressors of Epstein-Barr virus lytic reactivation
The Epstein Barr virus (EBV) is a human gammaherpesvirus which infects over 90% of the global population and is associated with lymphoid and epithelioid cancers. After infection, EBV enters a latent state in B-cells where the viral genome persists as a nuclear episome maintained by expression of a s...
ORGANISM(S): Homo sapiens (Human) 
2026-02-11 | PXD068122 | Pride
Epigenetics Virus activation Locus specific proteomics Polycomb complex Epstein-barr virus Virus latency Nurd complex De-ubiquitinase 
ProteomicsQuantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-Cov-2 innate immune evasion
We used two model systems to characterise the changes caused by SARS-CoV-2 using quantitative proteomics. We used primary human epithelial cells differentiated at the air-liquid interface, first describing the relative abundance of proteins found in each major cell type of the epithelium, and then c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD034135 | Pride
Sars-cov-2 Hbec 
ProteomicsTemporal proteomic analysis of HIV-Infection Reveals Remodelling of the Cellular Phosphoproteome by Phylogenetically Diverse Lentiviral Vif Variants
HIV accessory proteins manipulate host factors to evade cellular restriction and enhance viral replication. We used multiplex tandem mass tag (TMT)-based whole cell proteomics to gain a comprehensive, time-based overview of proteins and processes subverted during HIV infection. To make specific func...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD004187 | Pride
Hiv Whole cell proteome Tmt Temporal 
ProteomicsRegulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2
The regulation of membrane lipid composition is critical for cellular homeostasis. Cells are particularly sensitive to phospholipid saturation, with increased saturation causing membrane rigidification and lipotoxicity. How mammalian cells sense membrane lipid composition and reverse fatty acid (FA)...
ORGANISM(S): Homo sapiens (Human) 
2022-08-10 | PXD034835 | Pride
Ap-ms Tmt Oritrap fusion 
ProteomicsCell surface proteomic map of HIV infection reveals antagonism of amino acid metabolism by Vpu and Nef
Critical cell surface immunoreceptors downregulated by HIV have previously been identified using non-systematic, candidate approaches. To gain a comprehensive, unbiased overview of how HIV infection remodels the T-cell surface, we took a distinct, systems-level, quantitative proteomic approach. HIV ...
ORGANISM(S): Homo sapiens (Human) 
2015-11-09 | PXD002934 | Pride
Hiv Cell surface proteome Virus infection 
ProteomicsSARS-CoV2 manipulates multiple NK ligands and inhibits NK activation, but this can be overcome by ADNKA, which is strongly activated by non-Spike targeting antibodies
SARS-CoV2 is recognised the antagonise the interferon response, and functioning interferon responses are critical in determining the severity of disease. However, whether the virus antagonises cellular immunity has not been determined. We used quantitative plasma membrane proteomics in lung epitheli...
ORGANISM(S): Homo sapiens (Human) 
2022-05-26 | PXD025000 | Pride
Sars-cov2 Nk ligands Adnka 
UnknownA Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.
Not available
S-EPMC5025723 | biostudies-literature
ProteomicsEROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling.
The phagocyte NADPH oxidase is critical for host defence, and EROS (Essential for Reactive Oxygen Species) protein is indispensable for expression of its gp91phox-p22phox heterodimer. EROS deficiency in humans is a recently described cause of chronic granulomatous disease (CGD), but its mechanism of...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-30 | PXD025149 | Pride
Nox family Inflammasome Nadph oxidase Ost complex Chaperone T cells P2x receptor Er 
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
UnknownGenomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
Not available
S-EPMC8826310 | biostudies-literature
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