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GenomicsThe RNA-binding protein Rumpelstiltskin antagonizes gypsy chromatin insulator function in a tissue-specific manner
Chromatin insulators are DNA-protein complexes situated throughout the genome that contribute to higher order organization and demarcation into distinct transcriptional domains. Mounting evidence in different species implicates RNA and RNA-binding proteins as regulators of chromatin insulator activ...
ORGANISM(S): Drosophila melanogaster 
2014-04-18 | E-GEOD-51462 | biostudies-arrayexpress
ProteomicsDiscovery of a monoacylglycerol lipase inhibitor that harnesses the therapeutic potential of endocannabinoid signaling without CNS-mediated adverse side effects or physical dependence.
Chemical proteomics of LEI-515 in mouse lung, liver and brain tissue to assess the selectivity of the inhibitor.
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD042220 | Pride
Brain Lung Liver Mouse Chemical proteomics 
TranscriptomicsChronic alcohol consumption from adolescence-to-adulthood in mice M-bM-^@M-^T Effect on gene expression in the hypothalamus
We employed a paradigm of chronic moderate alcohol intake from adolescence-to-adulthood in mice, and analyzed the alcohol effect on both behavioral and hypothalamic gene expression changes. We employed a paradigm of chronic moderate alcohol intake from adolescence-to-adulthood in mice. Before chroni...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-42770 | biostudies-arrayexpress
UnknownOcta-coordinated alkaline earth metal-dinitrogen complexes M(N2)8 (M=Ca, Sr, Ba).
Not available
S-EPMC6662891 | biostudies-literature
Proteomicsmulberry lysate treated with oxyresveratrol
Identification of the biosynthetic enzyme of moracin M in mulberry through substrate based thermal proteome profiling
ORGANISM(S): Morus alba var. macroura Morus alba 
2026-04-30 | PXD058978 | Pride
Moracin m Thermal proteome profiling Oxyresveratrol Mulberry 
UnknownIridescence in nematics: Photonic liquid crystals of nanoplates in absence of long-range periodicity.
Not available
S-EPMC6744873 | biostudies-literature
TranscriptomicsGenes differentially expressed in Haloferax mediterranei strains, DF50 and M-NM-^TdeoR2, with or without induction by fructose
Transcriptional profiling of Haloferax mediterranei DF50 and M-NM-^TdeoR2 with induction by fructose comparing with the strains without this induction. Goal was to explore the effect of induction by fructose on Haloferax mediterranei. Total RNA from the Haloferax mediterranei DF50 and M-NM-^TdeoR2 w...
ORGANISM(S): Haloferax mediterranei 
2013-12-18 | E-GEOD-41134 | biostudies-arrayexpress
UnknownDevelopment of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids.
Not available
S-EPMC4731053 | biostudies-literature
GenomicsTissue-specific regulation of chromatin insulator function
Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein, Shep...
ORGANISM(S): Drosophila melanogaster 
2012-11-30 | E-GEOD-40797 | biostudies-arrayexpress
GenomicsThe dynamics of DNA methylation fidelity during mouse embryonic stem cell renewal and differentiation
Purpose: we aimed to gain a genome-wide view of the dynamics in DNA methylation inheritance and define the factors associated with methylation fidelity. Methods: Using mouse embryonic stem cell (ES-E14TG2a) in both undifferentiated and differentiated states as a model system, we exploited the hairpi...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-48229 | biostudies-arrayexpress
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