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TranscriptomicsComparative genomic hybridization of Leishmania mexicana wild type and glucose transporter (lmgt) knock-out strains show genomic adaptation
Genomic adaptation following glucose transporter knockout in leishmania mexicana
ORGANISM(S): Leishmania mexicana 
2008-12-01 | E-MEXP-1858 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Leishmania mexicana promastigotes, axenic amastigotes and intracellular amastigotes
We used Illumina sequencing of poly-A selected RNA of Leishmania mexicana (WHO strain MNYC/BZ/62/M379) culture-adapted promastigotes (PRO), axenic amastigotes (AXA) and intracellular amastigotes (AMA) in mouse bone marrow derived macrophages (BMDM), 24h after infection, to map 5' and 3' ends of Leis...
ORGANISM(S): Leishmania mexicana 
2015-09-11 | E-MTAB-3312 | biostudies-arrayexpress
ProteomicsThe mRNA-bound proteome of Leishmania mexicana is stage-regulated with distinct transcript target pools
Leishmania species parasite infections, termed the leishmaniases, cause significant global infectious disease burden. The lifecycle of the parasite embodies three main stages that require precise coordination of gene regulation to survive drastic environmental shifts transitioning from sandfly to ma...
ORGANISM(S): Leishmania Mexicana (ncbitaxon:5665) 
2018-10-11 | MSV000083023 | MassIVE
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
TranscriptomicsTranscript abundance comparison between BALB/c ears inoculated with Leishmania mexicana and Leishmania mexicana plus promastigote secretory gel (PSG)
To determine the modulation of gene expression of Leishmania mexicana(M379)-inoculated BALB/c ears in the presence of promastigote secretory gel (PSG) A genome-wide transcriptional analysis was performed by comparing the gene expression profiles of Leishmania mexicana- inoculated BALB/c ears and L...
ORGANISM(S): Mus musculus 
2013-12-17 | E-GEOD-52101 | biostudies-arrayexpress
MetabolomicsUntargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

BACKGROUND: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the potential for resistance to this d...

2019-09-26 | MTBLS1167 | MetaboLights
MetabolomicsMining for natural product antileishmanials in a fungal extract library
Leishmaniasis is a Neglected Tropical Disease caused by the insect-vector borne protozoan parasite, Leishmania species. Infection affects millions of the World’s poorest, however vaccines are absent and drug therapy limited. Recently, public-private partnerships have developed to identify new modes ...
2021-02-12 | MTBLS868 | MetaboLights
ProteomicsQueuosine-modified tRNA influences differentiation of Leishmania mexicana by codon bias translation
Using quantitative proteomics, we aim to compare the total proteome of L. mexicana wild (WT), knock-out (KO) and addback. The protein profile of all three will be related at five separate time points of life cycle differentiation. The objective is to elucidate the impact of Q-tRNA depletion on cellu...
ORGANISM(S): Leishmania mexicana 
2026-06-03 | PXD061534 | Pride
Leishmania mexicana Proteomics Queuosine Differentiation Timstof Translation 
TranscriptomicsIron uptake controls the generation of Leishmania infective forms through regulation of ROS levels .
During its life cycle Leishmania undergoes extreme environmental changes, alternating between insect vectors and vertebrate hosts. In mammals the parasites replicate within parasitophorous vacuoles of macrophages, compartments that contain low concentrations of iron. Here we show that stimulation of...
ORGANISM(S): Leishmania amazonensis 
2012-12-15 | E-GEOD-41641 | biostudies-arrayexpress
ProteomicsUnique Leishmania mexicana clones secrete populations of extracellular vesicles with unique protein profile and variable infectious capability
The study of extracellular vesicles has become an incredibly important field of study, but the inherent heterogeneity of these vesicles continues to make their study challenging. The genetic variability and well-documented protocols for the growth and vesicle isolation from Leishmania parasites prov...
ORGANISM(S): Leishmania mexicana 
2025-05-07 | PXD058429 | Pride
Exosomes Proteomics Extracellular vesicles Infectious disease Leismania mexicana Clonal cultures 
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