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TranscriptomicspiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | E-GEOD-38813 | biostudies-arrayexpress
TranscriptomicsPromoter capture-C of primary HepG2 cells
We employed a massively parallel, high resolution Capture-C based method to simultaneously characterize the genome-wide interactions of all human promoters in any cell type. We applied this approach to study the promoter interactome of HepG2 cells (3 biological replicates). We designed a custom Agil...
ORGANISM(S): Homo sapiens 
2019-03-20 | E-MTAB-7144 | biostudies-arrayexpress
TranscriptomicsNovel viruses naturally infecting Caenorhabditis nematodes trigger a small RNA response
C. elegans has served as a laboratory model organism due to its ease of manipulation and the availability of both forward and reverse genetics. In recent years, efforts to study host-pathogen interactions in C. elegans have increased. For example, analysis of infections by bacteria such as Pseudomon...
ORGANISM(S): Caenorhabditis elegans 
2011-01-01 | E-GEOD-21736 | biostudies-arrayexpress
TranscriptomicsFunction, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq)
piRNAs are required to maintain germline integrity and fertility but their mechanism of action is poorly understood. Here we demonstrate that C. elegans piRNAs silence transcripts in trans through imperfectly complementary sites. We find that target silencing is independent of Piwi endonuclease acti...
ORGANISM(S): Caenorhabditis elegans 
2012-06-18 | E-GEOD-28617 | biostudies-arrayexpress
UnknownMitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.
Not available
S-EPMC10244198 | biostudies-literature
TranscriptomicsGenotyping Tool for Studying Epidemiologically Related Isolates
Replicates of strains used in comparison of microarray to RAPD analysis for the publication. Findings from use of an open-reading frame-specific Campylobacter jejuni DNA microarray to investigate genetic diversity among clinical isolates associated with 5 independent clusters of infection were compa...
ORGANISM(S): Campylobacter jejuni 
2005-11-15 | E-GEOD-3610 | biostudies-arrayexpress
UnknownMitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes.
Not available
S-EPMC10083145 | biostudies-literature
ProteomicsProteomics on spermathecal fluid of BC queens
We sampled honey bee queens from beekeepers throughout British Columbia which were rated as either 'failed' or 'healthy' by beekeepers. We performed shot-gun proteomics on the spermathecal fluid (sperm removed). Proteins were reduced, alkylated, and digested with Lys-C for 4 h in urea digestion buff...
ORGANISM(S): Apis Mellifera 
2020-03-04 | MSV000085056 | MassIVE
UnknownKidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria.
Not available
S-EPMC6170432 | biostudies-literature
Unknownc-Kit modifies the inflammatory status of smooth muscle cells.
Not available
S-EPMC5472039 | biostudies-literature
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