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ProteomicsProteomic characterization of the heart and skeletal muscle reveals widespread Arginine ADP-ribosylation by the ectopic ADP-ribosyltransferase ARTC1
ADP-ribosylation has thus far been studied on the proteomic level mainly in cell lines and in combination with genotoxic stress. The clostridium-like ADP-ribosyltransferases (i.e. ARTC) are GPI-anchored or secreted proteins that are expressed in a highly tissue specific manner. Transcriptomic data r...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-17 | PXD008041 | Pride
Muscle Artc1 Ethcd Ptm Hcd Heart C2c12 Art1 Adp-ribosylation 
ProteomicsR2-P2 rapid-robotic phosphoproteomics enables multidimensional cell signaling studies
Recent developments in mass spectrometry-based proteomics have enabled systems-level studies of cellular signaling, where >10,000 phosphosites can be routinely identified and quantified. Yet, current analyses are limited in throughput, reproducibility, and robustness, hampering experiments that invo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-12-12 | PXD013453 | Pride
Phosphoproteomics / signaling / mapk / mass spectrometry / sp3 / dia/ r2-p2 
ProteomicsCellular heterogeneity and therapeutic response profiling of IDH-wildtype glioma stem cell cultures
Gliomas are the most common type of primary malignant adult brain tumor. They appear to originate from neuroglial stem or progenitor cells, and are therapeutically challenging due to an invasive growth pattern and the absence of effective therapies. We have analyzed cellular, molecular and proteomic...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD035886 | Pride
Cancer Stem cell Phopshoproteomics Glioblastoma Tumor 
ProteomicsThe regulatory landscape of the yeast phosphoproteome – quantitative phosphoproteomic DIA data
We systematically exposed the yeast Saccharomyces cerevisiae to a wide array of 101 perturbations and generated a quantitative mass spectrometry-based atlas of early phosphoproteomic responses. Perturbations covered broad classes of environmental, chemical, and drug perturbations and systematically ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-08-27 | PXD035050 | Pride
Signaling Dia Phosphoproteomics Orbitrap exploris 480 Ptm Saccharomyces cerevisiae Phosphatase Budding yeast R2-p2 Stress response Kinase Phosphorylation 
ProteomicsThe regulatory landscape of the yeast phosphoproteome – quantitative proteomics DIA data
We systematically exposed the yeast Saccharomyces cerevisiae to a wide array of 101 perturbations and generated a quantitative mass spectrometry-based atlas of early phosphoproteomic responses. Perturbations covered broad classes of environmental, chemical, and drug perturbations and systematically ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-08-27 | PXD034997 | Pride
Signaling Dia Orbitrap exploris 480 Stress response Saccharomyces cerevisiae Budding yeast R2-p2 
ProteomicsCellular ADP-ribosylome characterization with HCD and EThcD
Protein ADP-ribosylation is a post-translational modification involved in important physiological and pathological processes. Here, we present an optimized method using the Orbitrap Fusion Tribrid mass spectrometer, which drastically improves the overall ADP-ribosylation site localization score and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-28 | MSV000080008 | MassIVE
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