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MetabolomicsLC-MS metabolic profiling of mouse plasma and cell culture medium in relation to ABCC6 expression
Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by progressive ectopic mineralization of the skin, eyes and arteries, for which no effective treatment exists. PXE is caused by inactivating mutations in the gene encoding ABCC6 (MRP6), an ATP-dependent efflux transporter...
2013-11-14 | MTBLS61 | MetaboLights
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
TranscriptomicsMessenger RNA expression after MK2206/DMSO treatment of T47D cells
We performed RNA-seq in T47D cells after 24 hour treatment with the AKT inhibitor MK2206 or DMSO. We show that a group of transcripts is differentailly expressed after AKT inhibition. Comparison of mRNA levels using RNA-seq after AKT inhibition vs vehicle
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-80591 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of six pairs of affected and non-affected male F2 mice selected on the basis of their motor activity levels
Mice were obtained from in house breeding of C57BL/6J and C57BL/6J-Chr 1A/Na breeding pairs (Jackson Laboratories, USA). To produce F1 hybrids, C57BL/6J females were mated with C57BL/6J-Chr 1A/Na males. The F1 hybrids were intercrossed, producing 82 F2 progeny (41 males and 41 females). Microarray a...
ORGANISM(S): Mus musculus 
2006-12-31 | E-UMCU-22 | biostudies-arrayexpress
UnknownPerinatal depression among mothers in a South African birth cohort study: Trajectories from pregnancy to 18 months postpartum.
Not available
S-EPMC6851529 | biostudies-literature
UnknownSingle and Repeated Dose 28-Day and 13-Week Toxicity Studies of Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis) in Mice.
Not available
S-EPMC7353646 | biostudies-literature
UnknownProtein targets of reactive metabolites of thiobenzamide in rat liver in vivo.
Not available
S-EPMC2493440 | biostudies-literature
UnknownTechnical variability across the 450K, EPICv1, and EPICv2 DNA methylation arrays: lessons learned for clinical and longitudinal studies.
Not available
S-EPMC11583407 | biostudies-literature
ProteomicsIdentification of RNA-binding proteins involved in Rice yellow mottle virus infection
RNA-binding protein (RBP)-viral RNA interactions are essential for the viral life cycle and host cell. RNA viruses depend on host RBPs to accomplish their biological cycle; however, the compendium of RBPs involved in virus infection has remained poorly characterized. It has been demonstrated that su...
ORGANISM(S): Oryza sativa Indica Group x Oryza nivara 
2025-06-17 | PXD045853 | Pride
Lc-msms Rbps Saps Viruses Rymv Rbpome 
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