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ProteomicsMelanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture(RIC) to characterize the melanoma RBPome and uncover novel RBPs involved in melanoma progression. Comparison of RIC profi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD029927 | Pride
Rbp Mass spectrometry Melanoma 
ProteomicsRBPome of primary human T helper cells
Post-transcriptional gene regulation is complex, dynamic and ensures proper T cell function. The targeted transcripts can simultaneously respond to various factors as evident for Icos, an mRNA regulated by several RNA binding proteins (RBPs), including Roquin. However, fundamental information about ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-01 | PXD021164 | Pride
Human Rna interaction capture Rna binding proteins 
ProteomicsDefining the RBPome of T helper cells to study higher order post-transcriptional gene 1 regulation
Post-transcriptional gene regulation in T cells is dynamic and complex as targeted transcripts respond to various factors. This becomes evident for the Icos mRNA encoding an essential costimulatory receptorthatexhibits coordinate regulation by several RNA-binding proteins (RBPs), including Roquin-1 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD026716 | Pride
Bio-id Roquin Rbpome 
ProteomicsRBPome of primary mouse T helper cells
Post-transcriptional gene regulation by mRNA-binding proteins (RBPs) ensures an important layer to control protein outcome. It includes many fundamental processes, ranging from splicing to transport, decay and translation. Although recent technical developments allow the identification of mRNA-bindi...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-01 | PXD008830 | Pride
Rbp Mrna interactome capture Immune cells 
UnknownDefining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation.
Not available
S-EPMC8410761 | biostudies-literature
GenomicsMelanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
PRJNA731851 | ENA
ProteomicsRBPome of primary mouse T helper cells
Post-transcriptional gene regulation is complex, dynamic and ensures proper T cell function. The targeted transcripts can simultaneously respond to various factors as evident for Icos, an mRNA regulated by several RNA binding proteins (RBPs), including Roquin. However, fundamental information about ...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-01 | PXD022795 | Pride
Mouse Oops Rna binding proteins 
ProteomicsRBPome of primary human T helper cells
Post-transcriptional gene regulation is complex, dynamic and ensures proper T cell function. The targeted transcripts can simultaneously respond to various factors as evident for Icos, an mRNA regulated by several RNA binding proteins (RBPs), including Roquin. However, fundamental information about ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-01 | PXD021169 | Pride
Human Oops Rna binding proteins 
UnknownMelanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis.
Not available
S-EPMC9371929 | biostudies-literature
TranscriptomicsMelanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture (RIC) to characterize the melanoma RBPome and uncover novel RBPs involved in melanoma progression. Comparison of RIC prof...
ORGANISM(S): Homo sapiens 
2022-07-11 | GSE174821 | GEO
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