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TranscriptomicsRoquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs.
The degradation of TNFM-NM-1 mRNA is critical for restricting TNFM-NM-1 synthesis and involves a constitutive decay element (CDE) in the 3M-bM-^@M-^Y untranslated region of the mRNA. We demonstrate that the active CDE is a stem-loop RNA motif that is recognized by the RNA-binding protein Roquin. Dee...
ORGANISM(S): Mus musculus 
2013-05-15 | E-GEOD-44775 | biostudies-arrayexpress
TranscriptomicsExpression data from CD44loCD8+ T cells of sanroque versus wild-type mice
We used microarrays to detect the primary changes caused by the 'san' mutation in Roquin gene by comparing the gene expression profiles of naive (CD44lo) CD8+ T cell population. Sorted CD44loCD8+ T cells of age-matched sanroque (Roquinsan/san) and wild-type (Roquin+/+) mice in C57BL/6 background wer...
ORGANISM(S): Mus musculus 
2012-04-16 | E-GEOD-37319 | biostudies-arrayexpress
ProteomicsDefining the RBPome of T helper cells to study higher order post-transcriptional gene 1 regulation
Post-transcriptional gene regulation in T cells is dynamic and complex as targeted transcripts respond to various factors. This becomes evident for the Icos mRNA encoding an essential costimulatory receptorthatexhibits coordinate regulation by several RNA-binding proteins (RBPs), including Roquin-1 ...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD026716 | Pride
Bio-id Roquin Rbpome 
GenomicsAnalysis of Roquin targetome during HCMV infection
Analysis of Roquin targetome during HCMV infection
PRJNA545893 | ENA
UnknownSmall intestine inflammation in Roquin-mutant and Roquin-deficient mice.
Not available
S-EPMC3581552 | biostudies-literature
TranscriptomicsAnalysis of Roquin targetome during HCMV infection
To investigate how Roquin regulates cellular transcripts during Human cytomegalovirus (HCMV) infection, we examined the levels of cellular transcripts in cells treated control or Roquin-targeting siRNA during HCMV replication. Also, we performed Roquin crosslinking and immunoprecipitation followed b...
ORGANISM(S): Homo sapiens 
2019-08-15 | GSE132081 | GEO
UnknownSerous Cavity Mast Cells Depend on the ROQUIN Paralogs.
Not available
S-EPMC12716222 | biostudies-literature
UnknownRoquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
Not available
S-EPMC4346627 | biostudies-literature
UnknownRoquin Modulates Cardiac Post-Infarct Remodeling via microRNA Stability Control.
Not available
S-EPMC12651655 | biostudies-literature
GenomicsRNA-binding preference of the Roquin-1 CCCH-type zinc finger
RNA-binding preference of the Roquin-1 CCCH-type zinc finger
PRJNA1066235 | ENA
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