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ProteomicsIdentifying global and mtCU independent MICU1 interactome utilizing BioID2 based proximity labeling and screening
MICU1 is a Ca2+-binding protein that regulates the mitochondrial Ca2+ uniporter channel (mtCU ) and mitochondrial Ca2+ (mCa2+) uptake. MICU1 knockout mice display perinatal lethality and disorganized mitochondrial architecture. These phenotypes are distinct from other mtCU loss-of-function models an...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD028462 | Pride
Bioid2 Mitochondria Calcium Proximity-labelling Mcu Micu1 
ProteomicsNCLX proximity biotinylation screen
The mitochondrial sodium/calcium exchanger, NCLX, is critical to maintaining mitochondrial calcium homeostasis, yet little remains known about the mechanisms regulating its function. Here, we performed proximity biotinylation screening to identify the NCLX interactome and potential protein regulator...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000093004 | MassIVE
TranscriptomicsExpression data from Parkison's iPSCs with four copies of SNCA, and equivalent cell lines from an unaffected first degree relative
A major barrier to research on Parkinson’s disease (PD) is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells (iPSCs) from patients with PD and differentiate them into neurons affected by disease. We created an iPSC model of PD caused by triplicati...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30792 | biostudies-arrayexpress
GenomicsEGAD00000000119
Genotypes from cell lines derived from breast carcinoma tissue
EGAD00000000119 | EGA
GenomicsAssessment of genomic copy number alterations in breast cancer
The aim of this study was to assess genomic copy number alterations in a panel of breast cancer cell lines. These data were used to identify common aberrations associated with breast cancer, and also to identify aberrations associated with response to therapeutic compounds.
EGAS00000000059 | EGA
GenomicsBreast Cancer Cell Line Data Access Committee
Access to data is available by emailing application to the data access committee and will be granted to qualified investigators for appropriate use.
EGAC00000000015 | EGA
UnknownCommon variants at 6p21.1 are associated with large artery atherosclerotic stroke.
Not available
S-EPMC3651583 | biostudies-literature
UnknownEarly developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial.
Not available
S-EPMC3341507 | biostudies-literature
UnknownFactors associated with neurodevelopment for children with single ventricle lesions.
Not available
S-EPMC4356168 | biostudies-literature
UnknownCause, timing, and location of death in the Single Ventricle Reconstruction trial.
Not available
S-EPMC3539407 | biostudies-literature
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