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ProteomicsIn vivo and in vitro characterization and structural analysis of human DPCD protein in complex with RUVBL1/RUVBL2 AAA-ATPases
DPCD is a protein that may play a role in cilia formation and whose absence leads to primary ciliary dyskinesia (PCD), a rare disease caused by impairment of ciliated cells. Except for high-throughput studies that identified DPCD as a possible RUVBL1 (R1) and RUVBL2 (R2) partner, no in-depth cellul...
ORGANISM(S): Escherichia coli 
2023-04-06 | PXD031339 | Pride
Pcd Saxs Lumier-ip Silac Itc Em Xl-ms Structural ms. Nmr Dpcd Ruvbl1 Ruvbl2 
ProteomicsMembranes prime the RapGEF EPAC1 to transduce cAMP signaling
EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling in normal cells and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 activation in the cytosol. Her...
ORGANISM(S): Homo sapiens (Human) 
2023-04-07 | PXD040227 | Pride
Hdxms Epac1 
UnknownKynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα.
Not available
S-EPMC9296482 | biostudies-literature
UnknownSystematic analysis of blood cell transcriptome in end-stage chronic respiratory diseases.
Not available
S-EPMC4203719 | biostudies-literature
UnknownBlood Gene Expression Predicts Bronchiolitis Obliterans Syndrome.
Not available
S-EPMC5768645 | biostudies-literature
UnknownScalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.
Not available
S-EPMC6075717 | biostudies-literature
UnknownMachine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.
Not available
S-EPMC5918694 | biostudies-literature
UnknownOncogenic Signaling Pathways in The Cancer Genome Atlas.
Not available
S-EPMC6070353 | biostudies-literature
UnknownCell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
Not available
S-EPMC5957518 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
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