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Metabolomics4-Octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune response gene 1 (IRG1), has excellent potential to link immunity and metabolism in activated macrophages through alkylation or competitive inhibition of target proteins. In support of this, our previous study de...

2023-01-15 | MTBLS5877 | MetaboLights
ProteomicsOsteopontin Regulation of MerTK+ Macrophages Promotes Crohn’s Disease Intestinal Fibrosis
The pathogenesis of intestinal fibrosis in Crohn’s disease (CD) remains unclear. Mer receptor tyrosine kinase (MerTK) is an immunosuppressive protein specifically expressed in macrophages. Osteopontin (OPN), also known as secreted phosphoprotein 1, contributes to inflammation and wound repair. This ...
ORGANISM(S): Mus Musculus 
2024-05-31 | PXD052743 |
ProteomicsProteome profiling of intestine under DMXAA stimuli
Proteome profiling dataset of intestine under DMXAA stimuli.
ORGANISM(S): Mus Musculus 
2022-06-16 | PXD034614 |
ProteomicsEffects of 3D printing HUVEC(vefg165+) -laden hydrogel on diabetic wound healing
By constructing specific lentiviral vector, vefg165 protein was overexpressed in HUVEC cells. Using light-curing bioprinting, HUVEC(vefg165+)-loaded hydrogels and HUVEC(vector)-loaded hydrogels were prepared, and were used to treat rat diabetic wounds. The regenerated skin tissues (five samples for ...
ORGANISM(S): Rattus Norvegicus 
2022-08-12 | PXD036045 |
ProteomicsMacrophage MERTK restrains GRAMD1A‑driven mitochondrial cholesterol trafficking to limit colitis
Failed clearance of apoptotic cells drives pathogen persistence, tissue damage, and damage associated molecular patterns accumulation, fueling immune remodeling. Despite its pathophysiological significance, the precise immunometabolic reprogramming underlying impaired phagocytic signaling in macroph...
ORGANISM(S): Homo Sapiens 
2025-10-14 | PXD069433 |
UnknownTranscriptome analysis reveals critical factors for survival after adenovirus serotype 4 infection.
Not available
S-EPMC10070941 | biostudies-literature
UnknownGenetic spectrum and genotype-phenotype correlations in DNAH5-mutated primary ciliary dyskinesia: a systematic review.
Not available
S-EPMC11874857 | biostudies-literature
ProteomicsMapping novel biomarkers of liver injury by tissue proteomic analysis
Liver damage is a dynamic process and evaluation of liver injury degree is the key step in disease diagnose. However, few common markers between different types of liver injury have been reported. Herein, we generate three liver injury mouse models including Con A induced, CCl4 injected and subjecte...
ORGANISM(S): Mus Musculus 
2020-11-25 | PXD022716 |
ProteomicsEstablishment and clinical application evaluations of a deep mining strategy of plasma proteomics based on nanomaterial protein coronas
In this study, a deep mining strategy of plasma proteomics was established by combing the protein corona formed by deep mining beads (DMB beads, hereafter referred to as magnetic covalent organic frameworks Fe3O4@TpPa-1), DIA-MS detection and the DIA-NN library searching method.
ORGANISM(S): Homo Sapiens 
2023-05-31 | PXD042554 |
ProteomicsAlcoholic Liver Disease Human Serum Proteomics
Alcoholic liver disease LC-MS/MS quantitative proteomics with top14 abundant protein depletion
ORGANISM(S): Homo Sapiens 
2022-09-22 | PXD036941 |
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