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ProteomicsDevelopment of LC-FAIMS-MS and its application to lipidomics study of Acinetobacter baumannii infection
Here we present the development and application of LC-FAIMS-MS/MS based platform for untargeted lipidomics. The combination of normal phase liquid chromatography (NPLC), which can separate different types of phospholipids based on their head groups, and high-resolution MS (HRMS) offers a powerful qu...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055224 | Pride
Faims Lc-ms Acinetobacter baumannii Serum Lipidomics 
ProteomicsTMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early MSCs osteogenic differentiation
The intriThe intricate balance between MSCs differentiation to osteoblasts or adipocytes is finely regulated. To explore novel participating molecules, we screened for early-stage osteogenesis- or adipogenesis-based MSCs protein expression profile using TMT-based quantitative proteomic analysis. Pro...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD041404 | Pride
Marrow mesenchymal stem cells Differentiation Adipogenesis Human Osteogenesis 
UnknownApplication of ex-vivo spheroid model system for the analysis of senescence and senolytic phenotypes in uterine leiomyoma.
Not available
S-EPMC6265265 | biostudies-literature
UnknownMyometrial oxidative stress drives MED12 mutations in leiomyoma.
Not available
S-EPMC9308324 | biostudies-literature
TranscriptomicsAffymetrix Human Exon 1.0 ST array assay of 15 human MLL-associated samples and 9 human normal bone marrow [HuEx-1_0-st]
To identify potential target genes of leukemia-related miRNAs such as miR-196b and miR-150 in human MLL-associated leukemia, we performed Affymetrix Human Exon 1.0 ST array assay of 15 human MLL-associated samples and 9 human normal bone marrow (including 3 each of CD34+, CD33+, and MNC) cell sample...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-34184 | biostudies-arrayexpress
MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
TranscriptomicsIdentification of miR-181 target genes and a common prognostic gene signature in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30258 | biostudies-arrayexpress
UnknownOxidative stress-induced miRNAs modulate AKT signaling and promote cellular senescence in uterine leiomyoma.
Not available
S-EPMC6135677 | biostudies-literature
TranscriptomicsIdentification of prognostic gene signatures in AML
Increased expression levels of miR-181 family members have been shown to be associated with favorable outcome in patients with cytogenetically normal acute myeloid leukemia. Here we show that increased expression of miR-181a and miR-181b is also significantly (P < .05; Cox regression) associated wit...
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-30285 | biostudies-arrayexpress
TranscriptomicsAffymetrix gene arrays of leukemic BM samples from 24 mice including 9 primary
To identify such targets of leukemia-related miRNAs such as miR-196b, we conducted Affymetrix gene arrays of leukemic BM samples from 24 mice including 9 primary (including 3 each of negative control, MLL-AF9, and miR-196b+MLL-AF9) and 15 secondary (including 3 negative control, 6 MLL-AF9, and 6 miR...
ORGANISM(S): Mus musculus 
2012-08-09 | E-GEOD-34185 | biostudies-arrayexpress
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