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UnknownQuorum Quenching Enzyme (PF-1240) Capable to Degrade AHLs as a Candidate for Inhibiting Quorum Sensing in Food Spoilage Bacterium Hafnia alvei.
Quorum sensing (QS) is widely present in microorganisms in marine aquatic products. Owing to the use of antibiotics, many spoilage bacteria in aquatic products are drug resistant. In order to slow down this evolutionary trend, the inhibition of spoilage phenotype of spoilage bacteria by interfering ...
S-EPMC8622684 | biostudies-literature
UnknownPrognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma.

Background

The immune response within the tumor microenvironment plays a key role in tumorigenesis and determines the clinical outcomes of head and neck squamous cell carcinoma (HNSCC). However, to date, a paucity of robust, reliable immune-related biomarkers has been identified that are cap...
S-EPMC7390201 | biostudies-literature
ProteomicsBeclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival
Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its ECD...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD057003 | Pride
Beclin 1 Mouse Fetal liver 
ProteomicsBeclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis
Becn1 deficiency in the megakaryocytic lineage reduces sex hormone-binding globulin (SHBG), thus releasing testosterone into the blood and ultimately leading to increased bone mass and improved bone quality.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD058230 | Pride
Mouse Bone homeostasis Beclin1 
ProteomicsMulti-organ Proteomic and Phosphoproteomic Profiles of Mpox Virus Infection in SIVmac239-infected Rhesus Macaques
Macaque study was conducted in an ABSL-3 facility, adhering to protocols approved by the Institutional Animal Care and Use Committee (IACUC) under the guidelines of the Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (Approval Number XJ23004). All animals were single-hous...
ORGANISM(S): Macaca Mulatta 
PXD056753 |
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