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UnknownBiosynthesis of High-Active Hemoproteins by the Efficient Heme-Supply Pichia Pastoris Chassis.
Not available
S-EPMC10602571 | biostudies-literature
ProteomicsU1 Small Nuclear Ribonucleoprotein Complex and RNA Splicing Alterations in Alzheimer Disease
Comprehensive study of the human brain-insoluble proteome in AD by mass spectrometry. Mass spectrometry analysis of detergent insoluble fractions was processed based on our optimized LC-MS/MS protocol. Protein concentration was determined by bicinchoninic acid (BCA) assay (Thermo Scientific) using b...
ORGANISM(S): Homo sapiens (Human) 
2013-08-28 | PXD000067 | Pride
Human Splicing U170k Lc-ms/ms 
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
UnknownFGF22 deletion causes hidden hearing loss by affecting the function of inner hair cell ribbon synapses.
Not available
S-EPMC9366910 | biostudies-literature
ProteomicsUltra Deep Mouse cerebrospinal fluid (CSF) profiling in Alzheimer’s disease
Alzheimer's disease (AD) is a neurodegenerative disease, the most common cause of dementia in elderly persons. Accumulation of amyloid plaques in the brain is a characteristic of AD. The requirements for a biomarker include the ability to measure a pathologic process, predict outcome, distinguish di...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD018658 | Pride
Proteomics Alzheimer’s disease Mass spectrometry Mouse Csf Proteome Tandem mass tag Biomarker 
ProteomicsJUMPg: an Integrative Proteogenomics Pipeline Identifying Unannotated Proteins in Human Brain and Cancer Cells
Proteogenomics is an emerging approach to improve gene annotation and interpretation of proteomics data. Here we present JUMPg, an integrative proteogenomics pipeline including customized database construction, tag-based database search, peptide-spectrum match filtering, and data visualization. JUMP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080641 | MassIVE
UnknownDiscrimination and isolation of the virus from free RNA fragments for the highly sensitive measurement of SARS-CoV-2 abundance on surfaces using a graphene oxide nano surface.
Not available
S-EPMC8521082 | biostudies-literature
ProteomicsWhole proteome and phosphoproteome profiling of CD8+ and CD8- dendritic cells
Analyzing and comparing proteome and phosphoproteome profiling between CD8+ DC and CD8- DC not only will be very helpful to understand the molecular mechanisms regulating CD8+/- DC differentiation and function but also can screen CD8+ or CD8- DC specific regulatory pathways or molecules.
ORGANISM(S): Mus musculus (Mouse) 
2018-06-11 | PXD006875 | Pride
Mass spectrometry Proteomics Phosphoproteomics Dendritic cells 
ProteomicsAcetylome Profiling Reveals the Endogenous Substrates of HDAC6
HDAC6 inhibitors are novel targeted therapies showing good clinical response in a variety of different malignancies. However, their use and farther development is hampered by the limited knowledge regarding what are the endogenous substrates of HDAC6 enzyme. Here we plan to complete acetylome profil...
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD026010 | Pride
Mass spectrometry Hap1 cell Acetylome Proteomics 
ProteomicsDeep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Mus musculus (Mouse) 
2020-04-16 | PXD018590 | Pride
Tmt-lc/lc-ms/ms Brain Ad mouse model 
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