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ProteomicsDifferential Protein Expression in HK-2 Cells under Sodium Oxalate and Sodium Selenite Treatments (4D Label Free Proteomics)
This study aims to elucidate differential protein expression in HK-2 cells exposed to sodium oxalate and sodium selenite using 4D label free proteomics.
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD067701 | Pride
Hk-2 ferroptosis oxalate 
ProteomicsIdentification of Key Proteins and Pathways in Myocardial Infarction Using Machine Learning Approaches
Acute myocardial infarction (AMI) is a leading cause of global morbidity and mortality, requiring deeper insights into its molecular mechanisms for improved diagnosis and treatment. This study combines proteomics, multi-omics, and machine learning (ML) to identify key proteins and pathways associate...
ORGANISM(S): Homo Sapiens 
PXD062794 |
ProteomicsActivation of GPCR ligand binding genes revealed through degradation of RNA polymerase II
RNA polymerase II drives mRNA gene expression, yet our understanding of global Pol II repression is limited. Using auxin-inducible degron, we degraded Pol II's RPB1 subunit in mESCs, resulting in global repression, yet certain genes exhibited increased RNA levels post-degradation. These genes are as...
ORGANISM(S): Mus Musculus 
PXD048023 |
ProteomicsEIF4G2 Promotes HCC Progression
Aberrant translation from mRNAs to proteins plays a crucial role in the pathogenesis of various cancers. Here, we revealed that the key proteins involved in translation were up-regulated in two hepatocellular carcinoma (HCC) cohorts. Specifically, we identified the translation initiation factor EIF4...
ORGANISM(S): Homo Sapiens 
PXD052695 |
ProteomicsThe changes in lysine acetylation levels of Bacillus altitudinis 6ww6 under salt stress
Applied the quantitative acetylome analysis technique to identify the up-regulated and down-regulated acetylation sites of proteins from Bacillus altitudinis under salt stress, and found that differentially acetylated proteins under salt stress mainly focused on energy generation and conversion, ami...
ORGANISM(S): Bacillus Altitudinis 
PXD056209 |
ProteomicsApplication of an iPSC-derived Organoid Model for Located Scleroderma Therapy
Scleroderma is a chronic connective tissue disease characterized by skin thickening and plaque morphea, as well as hard, shiny skin. Serious involvement is observed from the superficial dermis down to the fascia and muscle. However, this condition is difficult to treat and evaluate. In this study, i...
ORGANISM(S): Mus Musculus 
2021-04-26 | PXD025613 |
ProteomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity
RNA polymerase II (Pol II) subunits are thought to be involved in various transcription-associated processes, but it is unclear whether they play different regulatory roles in modulating gene expression. Here, we performed nascent and mature transcript sequencing after the acute degradation of 12 ma...
ORGANISM(S): Mus <genus> 
PXD035866 |
ProteomicsTime-resolved extracellular matrix atlas of the developing human skin dermis
Skin aging is a physiological problem that remains a concern. Studies have demonstrated that the dermal extracellular matrix (ECM) plays important roles in skin aging; however, changes in ECM characteristics and molecules that are secreted to the extracellular space and involved in the formation of ...
ORGANISM(S): Homo Sapiens 
2022-11-28 | PXD016440 |
ProteomicsOLFM4 is a direct target of the cGAS-STING pathway and acts as an extracellular inhibitor for the Hippo signaling in EBV-associated cancer
To investigate protein components of MVs in EBVaGC, we collected clinical tissue samples of 3 EBV+ and 3 EBV- gastric cancer patients, and isolated MVs from these samples. Then performed 4D-label free quantitative proteomics analysis for each isolated MVs. Raw files of 6 samples are included in subp...
ORGANISM(S): Homo Sapiens 
2024-11-18 | PXD057977 |
ProteomicsMyocardial Mitochondrial Antiviral Signaling Protein Promotes Heart Ischemia-reperfusion Injury via RIG-I Signaling-proteomic sequencing
Myocardial ischemia-reperfusion injury (MIRI) is a life-threatening complication of myocardial infarcts, with inner mitochondrial membrane protein dysfunction involved in MIRI-induced heart injury. The role of outer mitochondrial membrane protein MAVS is unknown. Here we show that MAVS expression in...
ORGANISM(S): Mus Musculus 
2025-03-20 | PXD062097 |
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