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ProteomicsIsobaric labeling strategy utilizing 4-plex N, N-dimethyl leucine (DiLeu) tags reveals proteomic changes induced by chemotherapy-related neurotoxicity in cerebrospinal fluid of children
Using mass spectrometry for protein identification and quantification in cerebrospinal fluid (CSF) is at the forefront of research efforts to explore the pathophysiology biomarkers for the early diagnosis and prognosis of neurologic disorders. Here we implemented 4-plex N, N-dimethyl leucine (DiLeu)...
ORGANISM(S): Homo sapiens (Human) 
2020-07-02 | PXD017415 | Pride
Leukemia Isobaric labeling Csf proteomics 
ProteomicsEnrichment and Fragmentation Approaches for Enhanced Detection and Characterization of Endogenous Glycosylated Neuropeptides
Glycosylation, a common and heterogeneous post-translational modification plays a key role in altering biomolecule function and other properties. Prior to monitoring regulatory roles, basal glyconeuropeptide expression must be determined. Characterization is partially limited by the lower abundance ...
ORGANISM(S): Callinectes sapidus 
2022-08-19 | PXD033226 | Pride
Glycosylation Neuropeptides Endogenous peptides Mass spectrometry De novo sequencing 
ProteomicsExploring the Sexual Dimorphism of Crustacean Neuropeptide Expression using Callinectus sapidus as a Model Organism
The impact of numerous diseases has been linked to differences in sex between organisms, including various neurological diseases. As neuropeptides are known to be key players in the nervous system, studying the variation of neuropeptidomic profiles between males and females in a crustacean model org...
ORGANISM(S): Callinectes Sapidus (ncbitaxon:6763) 
2020-07-05 | MSV000085694 | MassIVE
ProteomicsIn-depth site-specific O-glycosylation analysis of glycoproteins and endogenous peptides in cerebrospinal fluid (CSF) from healthy individual mild cognitive impairment (MCI) and Alzheimer disease (AD) patients
Site-specific O-glycoproteome mapping in complex biological system provides molecular basis for understanding the structure-function relationships of glycoproteins and their roles in physiological and pathological processes. Previous O-glycoproteome analysis in cerebrospinal fluid (CSF) focused on s...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-05 | MSV000087160 | MassIVE
ProteomicsProtein citrullination and homocitrullination profiling in mice using LC-MS/MS
Citrullination and homocitrullination are two post-translational modifications (PTMs) that may cause protein structural and functional changes. Although they have been linked to various biological processes and disease development, the understanding is still poor because of limitations to enrich, de...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-05 | PXD023733 | Pride
Citrullination Mouse Biotin thiol tag Homocitrullination Lc-ms/ms 
ProteomicsLC-MS/MS of proteomics in human ovarian cancer versus control samples
We investigated how the proteome changed in human patients with ovarian cancer compared with healthy individuals.
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD025864 | Pride
Human Ovarian cancer Proteomics Lc-ms/ms 
ProteomicsLC-MS/MS of different developmental stages of human pancreas
Mass spectrometry-based quantitative proteomics was used to delineate proteome-wide and extracellular matrix (ECM) alterations at four age groups in human pancreas: fetal (18-20 weeks gestation), juvenile (5-16 years old), young adults (21-29 years old) and older adults (50-61 years old).
ORGANISM(S): Homo sapiens (Human) 
2021-01-06 | PXD020130 | Pride
Human Pancreas Matrisome Developmental stages Lc-ms/ms 
TranscriptomicsMolecular insights into DDX3X–mRNA regulation in castration-resistant prostate cancer
RNA-immunoprecipitation sequencing (RIP-seq) was performed to identify the transcripts under the regulation of DEAD-box helicase 3 X-linked (DDX3X). The BPH1-derived Cancer Progression (BCaP) cell lines were used for RIP-seq. Input and RIP RNA from the androgen receptor low/negative castration-resis...
ORGANISM(S): Homo sapiens 
2026-04-17 | E-MTAB-15800 | biostudies-arrayexpress
MetabolomicsGut Microbial and Metabolic Responses to Salmonella enterica Serovar Typhimurium and Candida albicans

The gut microbiota is increasingly recognized for playing a critical role in human health and disease, especially in conferring resistance to both virulent pathogens such as Salmonella, which infects 1.2 million people in the United States every year [1], and opportunistic pathogens like Candida,...

2019-09-20 | MTBLS753 | MetaboLights
ProteomicsIn depth quantification of extracellular matrix proteins from human pancreas
Extracellular matrix (ECM) is an important component of the pancreatic microenvironment which regulates β cell proliferation, differentiation and insulin secretion. Protocols have recently been developed for the decellularization of the human pancreas to generate functional scaffolds and hydrogels. ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-17 | PXD012460 | Pride
Tissue engineering Sample preparation Quantitative proteomics Ecm 
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