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ProteomicsMass spectrometry analysis of post-translational modifications of K/C-III-expressing HEK293T cells treated by A485 for 6 and 12 hours
To determine whether CBP/P300 HAT activity is essential for leukemia cell maintenance, we utilized the selective acetyltransferase inhibitor A485. Mass spectrometry analysis of post-translational modifications showed that A485 treatment of K/C-III-expressing HEK293T cells for 6 and 12 hours signific...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD061565 | Pride
Human A485 Post-translational modification K/c-iii Lc-faims-ms/ms 
ProteomicsImmunoprecipitation and mass spectrometry (IP-MS) on KAT6A chimeras
Despite KAT6A chimeras potent oncogenic activity, the mechanisms by which KAT6A fusion proteins achieve genomic specificity and drive leukemogenesis remain poorly understood. Previous studies suggest that the leukemogenic potential of KAT6A-TIF2 depends on its chromatin-binding ability rather than i...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD061491 | Pride
Human Ip-ms. Kat6a fusion Immunoprecipitation Kat6a n-terminus 
ProteomicsCDK12 and Integrator-PP2A complex Modulates LEO1 Phosphorylation for Processive Transcription Elongation
Cyclin-dependent kinase 12 (CDK12) interacts with Cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD). To gain a broader understanding of CDK12 cellular function, we used chem...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD038558 | Pride
Cdk12 Transcription elongation Analog-sensitive kinase Rna polymerase ii Leo1 Paf1 complex Intac complex 
TranscriptomicsMitotic Transcriptional Clearance of Actively Engaged Pol II Through Transcriptional Elongation Control
Chromatin is highly condensed and transcriptionally repressed during mitosis. Although it is established that some general transcription factors are inactivated by phosphorylation at mitosis, many details of mitotic transcriptional repression and its underlying mechanisms are largely unknown. Here, ...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-71848 | biostudies-arrayexpress
ProteomicsCo-immunoprecipitation of G-quadruplex-containing Core Promoter and nanoLC-FAMIS-MS/MS
G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-association of guanines, and they are distributed widely across the genome. G4 participates in multiple biological processes including gene transcription, and G4-targeted ligands serve as potential therapeutic age...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD026830 | Pride
Human Core promoter Co-immunoprecipitation G-quadruplex Nuclear protein Nanolc-famis-ms/ms 
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