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TranscriptomicsTranscription profiling of mouse skins of embryos lacking Grainyhead-like epithelial transactivator (Get-1)
Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grhl3, a conserved mammalian homologue...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7381 | biostudies-arrayexpress
UnknownAntitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742).
Not available
S-EPMC5941615 | biostudies-literature
ProteomicsPLK1 inhibition selectively induces apoptosis in ARID1A deficient cells through uncoupling of oxygen consumption from ATP production
Inhibitors of the mitotic kinase PLK1 yield objective responses in a subset of refractory cancers. However, PLK1 overexpression in cancer does not correlate with drug sensitivity, and the clinical development of PLK1 inhibitors has been hampered by the lack of patient selection marker. Using a high-...
ORGANISM(S): Homo sapiens (Human) 
2022-03-08 | PXD031110 | Pride
Oxidative phosphorylation Mitochondria Plk1 Arid1a Synthetic lethality 
ProteomicsGlobal analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis
In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. RNA-binding proteins (RBPs) are a large class of post-transcriptional regulators that have been increasingly implicated in carcinogenesis. By integrating mul...
ORGANISM(S): Homo sapiens (Human) 
2022-03-10 | PXD030215 | Pride
Post-transcriptional regulation Larp1 Myc Rna-binding protein Cancer 
UnknownmicroRNA-193-3p attenuates myocardial injury of mice with sepsis via STAT3/HMGB1 axis.
Not available
S-EPMC8428118 | biostudies-literature
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
UnknownA simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes.
Not available
S-EPMC7793621 | biostudies-literature
UnknownThe Natural Helper approach to culturally responsive disease management: protocol for a type 1 effectiveness-implementation cluster randomised controlled trial of a cultural mentor programme.
Not available
S-EPMC9884889 | biostudies-literature
MetabolomicsMulti-omic analysis of vaginal bacteria:host immune and metabolic interactions in early adverse pregnancy outcomes

Objective

To characterise the vaginal microbiota, mucosal metabolome and host immune response in early pregnancy and investigate its relationship with adverse pregnancy outcomes, including ectopic pregnancy, within the context of pregnancies of unknown location (PUL).

<...
2025-03-28 | MTBLS10098 | MetaboLights
UnknownResidual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury.
Not available
S-EPMC12860639 | biostudies-literature
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