Sort   by:  
 Page size 
Proteomicsrole of LIN28B protein in medulloblastoma by siRNA-mediated silencing of LIN28B in Daoy cells
To understand the role of LIN28B protein in medulloblastoma by siRNA-mediated silencing of LIN28B in Daoy cells and analysing the differentially-regulated proteins and pathways.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD022481 | Pride
Medulloblastoma Sirna Lin28b 
ProteomicsThe Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epithelium
Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment (TME) is important for tumor development. Here we showed that Lin28b/let-7 pathway is indispensable for modulating the expression of Wnt5a in tumor epithelium, which could be secreted and then up-regulates Li...
ORGANISM(S): Mus Musculus 
PXD045477 |
GenomicsLIN28B siRNA+BMN673
LIN28B siRNA+BMN673
PRJNA1255576 | ENA
TranscriptomicsLIN28B and colon cancer
This SuperSeries is composed of the following subset Series: GSE26334: Expression data from LoVo colon cancer lines +/- constitutive LIN28B expression GSE26335: Expression data from xenograft tumors derived from LoVo colon cancer lines +/- constitutive LIN28B expression Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-12-29 | E-GEOD-26336 | biostudies-arrayexpress
ProteomicsThe OTUD6B-LIN28B-MYC axis determines cell cycle progression in multiple myeloma
Deubiquitylases (DUBs) remove ubiquitin from proteins. In the context of cancer, their inhibition can induce the degradation of oncoproteins, that may otherwise be “undruggable”. Multiple myeloma (MM) is the second most common hematological malignancy with poor outcome and high sensitivity towards u...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD027480 | Pride
Bioid Human Flag-ip Orbitrap Otud6b 
ProteomicsC/EBPβ-LIP regulates the let-7/Lin28b circuit to induce cancer-type metabolic reprogramming
The RNA binding protein Lin28b is highly expressed during embryogenesis but its expression declines in adult tissues, and aberrant expression of Lin28b is associated with tumour development and maintenance. Lin28b regulates the translation of several glycolytic and mitochondrial enzymes in order to ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010095 | Pride
Q exactive hf Shotgun proteomics 
TranscriptomicsRegulation of Lin28b and let-7 in developmental myelopoiesis
We isolated RNA from sorted common myeloid progenitor cells from wild-type fetal liver, wild-type adult bone marrow, transgenic Lin28b bone marrow, let-7b/c knock-out bone marrow, and Lin28b-deficient fetal liver and compared mRNA expression profiles. Examination of mRNA expression in common myeloid...
ORGANISM(S): Mus musculus 
2016-06-26 | E-GEOD-72521 | biostudies-arrayexpress
TranscriptomicsExpression data from xenograft tumors derived from LoVo colon cancer lines +/- constitutive LIN28B expression
We sought to elucidate functions of LIN28B and potential mechanisms whereby it may promote metastasis by comparing the gene expression profile of LIN28B metastases to primary tumors. Accordingly, we performed microarray analysis on total RNA isolated from empty vector tumors, LIN28B-LoVo tumors, and...
ORGANISM(S): Homo sapiens 
2010-12-29 | E-GEOD-26335 | biostudies-arrayexpress
TranscriptomicsInactivation of the exosome ribonuclease DIS3 triggers the pluripotency factor LIN28B, repressing let-7 miRNAs and unleashing MYC and RAS.
Somatic mutations affecting DIS3, the catalytic component of the RNA exosome, have been found in up to 18% of patients affected by the hematological cancer multiple myeloma. Here we show that DIS3 targets and degrades the pluripotency factor LIN28B. In cancer cells, DIS3 inactivation leads to enhanc...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-55246 | biostudies-arrayexpress
TranscriptomicsLin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a [Lin28b & Let7 transduction]
Mouse B cell precursors from fetal liver and adult bone marrow generate distinctive B cell progeny when transplanted into immunodeficient recipients, supporting a two-pathway model for B lymphopoiesis, fetal “B-1” and adult “B-2”. Recently Lin28b was shown to be important for the switch between feta...
ORGANISM(S): Mus musculus 
2015-03-01 | E-GEOD-65534 | biostudies-arrayexpress
Sort   by:  
 Page size