Sort   by:  
 Page size 
MetabolomicsATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth

Lipid droplet (LD) growth mechanisms and the roles of LD-associated lipid transfer proteins remain poorly understood. Here, we show that the autophagy lipid transfer protein ATG2A has an anabolic role and promotes LD expansion by transferring diacylglycerol (DAG), and potentially triacylglycerol ...

2025-09-07 | MTBLS12951 | MetaboLights
GenomicsExamination of hepatic SREBP-2 binding using ChIP-Seq
Sterol regulatory element binding proteins (SREBPs) are key transcriptional regulators of lipid metabolism. To define functional differences between the three mammalian SREBPs we are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28082 | biostudies-arrayexpress
ProteomicsIdentification of Novel Lipid Droplet Factors that Regulate Lipophagy and Cholesterol Efflux in Macrophage Foam Cells
Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy relies on tags such as ubiquitin and a set of selectivity factors including selective autophagy receptors (SARs) to lab...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD017511 | Pride
Human Lipid droplet Macrophage foam cell Lc-ms/ms 
ProteomicsRAB18 impacts autophagy via lipid droplet-derived lipid transfer and is rescued by ATG9A
Autophagy is a lysosomal degradation pathway that mediates protein and organelle turnover and maintains cellular homeostasis. Autophagosomes transport cargo to lysosomes and their formation is dependent on an appropriate lipid supply. Here, we show that the knockout of the RAB GTPase RAB18 interfere...
ORGANISM(S): Homo sapiens (Human) 
2020-01-29 | PXD013719 | Pride
Human Atg2b Rab18 Atg9a Lc-ms/ms 
UnknownThe constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
Not available
S-EPMC5529083 | biostudies-literature
TranscriptomicsExpression data from CH/LE Mice
We are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with different dietary conditions that enrich for specific SREBPs. We show that hepatic SREBP-2 binds preferentially to two different gene-proximal motifs as well as SREBP-2 dire...
ORGANISM(S): Mus musculus 
2011-03-22 | E-GEOD-28083 | biostudies-arrayexpress
TranscriptomicsGenome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Novel Role in Autophagy
This SuperSeries is composed of the following subset Series: GSE28082: Examination of hepatic SREBP-2 binding using ChIP-Seq GSE28083: Expression data from CH/LE Mice Refer to individual Series
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-28084 | biostudies-arrayexpress
ProteomicsQuantitative mass spectrometry of HAX1 WT and HAX1 KO promyelocytic cells reveal differences in amino acid synthesis and lipid metabolism
part of a project: Granulocyte differentiation arrest in HAX1-deficient cells demonstrated in a new in vitro model of Kostmann disease, is caused by ineffective lipid droplet autophagy and fatty acids uptake. Molecular and metabolic mechanisms underlying congenital neutropenia in patients with HAX1 ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-22 | PXD064511 | Pride
Hax1 Lipid metabolism Lipid droplet autophagy Kostmann disease Neutrophil differentiation 
UnknownAMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA.
Not available
S-EPMC4835968 | biostudies-literature
UnknownA new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy.
Not available
S-EPMC12463273 | biostudies-literature
Sort   by:  
 Page size