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MetabolomicsATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth

Lipid droplet (LD) growth mechanisms and the roles of LD-associated lipid transfer proteins remain poorly understood. Here, we show that the autophagy lipid transfer protein ATG2A has an anabolic role and promotes LD expansion by transferring diacylglycerol (DAG), and potentially triacylglycerol ...

2025-09-07 | MTBLS12951 | MetaboLights
MetabolomicsRetromer mediates Ypt7-dependent lipid droplet internalization

Lipid droplets (LDs) are dynamic organelles central to cellular energy homeostasis and stress adaptation. Maintaining LD balance is critical for cell function, yet the mechanisms governing selective LD degradation remain unclear. Here, we reveal a pathway promoting efficient vacuolar sequestering...

2026-07-15 | MTBLS15038 | MetaboLights
MetabolomicsHERPES SIMPLEX VIRUS TYPE 1 IMPAIRS DENDRITIC CELL FUNCTION BY REMODELLING NEUTRAL LIPID METABOLISM AND INDUCING LIPID DROPLET ACCUMULATION
Herpes simplex virus type 1 (HSV-1) infects dendritic cells (DCs), professional antigen-presenting cells that initiate and regulate host antiviral responses. HSV-1 infects DCs limiting their maturation, migration to draining lymph nodes and T cell activation capacity, ultimately promotes their apopt...
2025-04-03 | MTBLS5163 | MetaboLights
MetabolomicsOxygen-induced pathological angiogenesis promotes intense lipid synthesis and remodeling in the retina

The retina is a notable tissue with high metabolic needs which relies on specialized vascular networks to protect the neural retina while maintaining constant supplies of oxygen, nutrients and dietary essential fatty acids. Here we analyzed the lipidome of the mouse retina under healthy and patho...

2023-05-09 | MTBLS6965 | MetaboLights
ProteomicsQuantitative proteomics of lipid droplets from goose hierarchical granulosa cells and pre-hierarchical granulosa cells
The lipid metabolism of granulosa cells plays a pivotal role in the development of goose follicles. However, the mechanisms by which lipid droplet-associated proteins regulate lipid droplets and influence cellular lipid metabolism remain poorly understood. To address this, our study systematically i...
ORGANISM(S): Anser cygnoides 
2025-03-26 | PXD061272 | Pride
Goose Granulosa cell Lipid droplets 
ProteomicsIdentification of a lipid droplet-plasma membrane tethering complex
Membrane contact sites (MCS) are interorganellar contacts that allow for the direct exchange of molecules such as lipids or Ca2+ between organelles, but can also be a mean for tethering of organelles. In mammals and yeast, LDs have been shown to engage in MCS with nearly all organelles in the cell, ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-06-09 | PXD022769 | Pride
Seedling Membrane contact sites Arabidopsis Tag Tethering complex Seed Lipid droplets Germination Plasma membrane 
ProteomicsTurboID-based proximity labeling of ER-localized TMEM120A/B interactome in Oleic Acid-treated HEK293T cells
Raw mass spectrometry data (.d raw data from Bruker) supporting the study: "A conserved ER protein prevents lipotoxicity by stimulating the key enzyme in glycerolipid synthesis". This dataset contains LC-MS/MS raw files from a proximity labeling experiment (TurboID) designed to identify interacting ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD075982 | Pride
Proximity labeling Turboid Tag Lipid droplet 
ProteomicsData on the change in the protein profiles of human subcutaneous white adipocytes during differentiation and maturation
We analyzed changes in the protein profiles that occur during differentiation and maturation of cultured human subcutaneous white preadipocytes. We divided the three cell lines (Cell Line-1, Cell Line-2, and Cell Line-3) of Caucasian-derived subcutaneous preadipocytes into five stages: i) subcutaneo...
ORGANISM(S): Homo Sapiens (human) 
2022-07-04 | PXD035060 | JPOST Repository
TranscriptomicsIntegrated omics studies delineate the formation and dynamics of lipid droplets in Rhodococcus opacus PD630 for biofuel feedstock
Purpose: To delineate mechanisms underlying lipid storage in LDs, we compared the transcriptomes of cells cultivated under three lipid-accumulating conditions. Methods: PD630 mRNA profiles of 3 different conditions (normal condition and LDs acculation conditions) were generated by deep sequencing, u...
ORGANISM(S): Rhodococcus opacus 
2013-11-04 | E-GEOD-42381 | biostudies-arrayexpress
ProteomicsThe lipid droplet protein DHRS3 is a regulator of melanoma cell state
Lipid droplets are fat storage organelles composed of a protein envelope which surrounds a lipid rich core. Dynamic regulation of this protein envelope underlies differential lipid droplet formation and function in diverse cell types. In melanoma, the ability to form lipid droplets has been linked t...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD050693 | Pride
Lipid droplet Dhrs3 Melanoma Human 
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