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MetabolomicsDifferent regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly
Vesicle associated membrane protein 2 (VAMP2/synaptobrevin2), a core SNARE protein residing on synaptic vesicles (SVs), forms helix bundles with syntaxin-1 and SNAP25 for the SNARE assembly. Prior to the SNARE assembly, the structure of VAMP2 is unclear. Here, by using in-cell NMR spectroscopy, we d...
2021-10-06 | MTBLS1503 | MetaboLights
ProteomicsThe Lipid Raft Proteome of Borrelia burgdorferi.
Eukaryotic lipid rafts are membrane microdomains rich in cholesterol that contain a selective set of proteins, and have been associated with multiple biological functions. The Lyme disease agent, Borrelia burgdorferi, is one of an increasing number of bacterial pathogens that incorporates cholestero...
ORGANISM(S): Borrelia burgdorferi B31 
2015-09-21 | PXD002365 | Pride
Bacteria Lyme disease Lipid raft Prokaryotes Borrelia 
ProteomicsOvarian Cancer Lipid raft proteomics and role of OPCML
ipid rafts are dynamic membrane micro-domains that orchestrate molecular interactions and are implicated in cancer development. To understand potential role of tumor suppressor OPCML on the altered dynamics of lipid raft residing proteins, we performed quantitative (SILAC) proteomics experiment. We ...
ORGANISM(S): Homo sapiens (Human) 
2017-03-16 | PXD006078 | Pride
Skov-3 Silac P95r opcml Lipid raft Opcml 
TranscriptomicsmRNA expression data from keratinocytes with disorganized lipid raft structures (by cholesterol depletion by methyl-beta-cyclodextrin)
Lipid rafts are cholesterol-rich cell signaling platforms and their physiological role can be explored by cholesterol depletion. To dress a global picture of transcriptional changes ongoing after lipid raft disruption, we performed whole-genome expression profiling in epidermal keratinocytes, a cell...
ORGANISM(S): Homo sapiens 
2010-04-17 | E-GEOD-21364 | biostudies-arrayexpress
ProteomicsA sensitive S-trap-based approach to the analysis of T-cell raft proteome
The development of sensitive technologies for T cell-raft proteomics is highly challenging. We explored an innovative strategy, based on suspension trapping (S-trap) sample preparation. Mouse splenocytes were subjected to negative immunoselection for T cell preparation. Rafts were isolated by a dete...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-08-13 | PXD016476 | Pride
T cell Optiprep Raftomics Fasp S-trap Detergent-free 
ProteomicsComposition of raft-like cell membrane microdomains resistant to styrene-maleic acid copolymer (SMA) solubilization
An advantageous alternative to the use of detergents in biochemical studies on membrane proteins have recently been styrene-maleic acid (SMA) amphipathic copolymers. These cut the membrane into nanodiscs (often called SMA-lipid particles, SMALPs), which contain membrane proteins surrounded by their ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD031828 | Pride
Sma Lipid rafts 
MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
ProteomicsPerturbation of JAK-STAT signaling in macrophages by arachidonic acid with implications for the ovarian cancer microenvironment
Progression and relapse-free survival of ovarian carcinoma are associated with the abundance of immunosuppressed CD163highCD206high tumor-associated macrophages (TAMs) and high levels of polyunsaturated fatty acids (PUFAs), in particular arachidonic acid (AA), in the tumor microenvironment. In the ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD028434 | Pride
Ovarian cancer  arachidonic acid  monocyte-derived macrophages  tumor associated macrophages  macrophages  jak/stat  lipid rafts 
GenomicsMAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells.
MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells.
PRJNA779151 | ENA
GenomicsLPC 18:2-Driven Apoptosis In Neutrophils Is Non-Inflammatory and Lipid Raft Dependent
LPC 18:2-Driven Apoptosis In Neutrophils Is Non-Inflammatory and Lipid Raft Dependent
PRJNA1368605 | ENA
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