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TranscriptomicsRequirement for Lis1 in normal and malignant hematopoietic stem cell renewal to investigate requirement for Lis1 in normal and malignant hematopoietic stem cell renewal
Adult Lis1+/+creER or Lis1f/fcreER mice were treated with tamoxifen for five consecutive days. Three days after the final tamoxifen administration, KLS (ckit+ Lin- Sca1+) bone marrow cells were FACS-sorted and total cellular RNAs were purified. RNAs were amplified, labeled, hybridized onto Affymetr...
ORGANISM(S): Mus musculus 
2014-02-02 | E-MEXP-3855 | biostudies-arrayexpress
ProteomicsLIS1 RNA binding orchestartes the mechanosensitive properties of embryonic stem cells in AGO2 dependent and independent ways.
LIS1 immunoprecipitation in nuclear and cytoplasmic fractions of LIS1 Floxed/-, OE and WT embryonic stem cells. To identify AGO2 dependent and independent interactions LIS1 was immunoprecipitated in AGO1-4 knockout and doxycycline induced AGO2 mouse embryonic stem cells.
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD033150 | Pride
Oe Dox.ago2 Ago1-4 ko Nuclear and cytoplasmic fractions Flox/- Wt Mouse embyonic stem cells Lis1 ip 
GenomicsLIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways [3_seCLIP_seq]
LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways [3_seCLIP_seq]
PRJNA814670 | ENA
ProteomicsPrecise temporal regulation of post-transcriptional repressors is required for an orderly Drosophila maternal-to-zygotic transition
In animal embryos the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents over half of the protein coding capacity of the Drosophila melanogaster genome and that 2% of this proteome is rapidly degraded...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-09-09 | PXD018794 | Pride
C-terminal to lis1 homology (ctlh) complex Skp/cullin/f-box-containing (scf) complex Ubiquitin ligase Smaug Rna-binding protein 
TranscriptomicsMyelodysplastic Syndromes (MDS) and Acute Myeloid Leukaemia (AML)
A 10K cDNA microarray was used to compare neutrophil RNA from 21 MDS patient and 2 AML patients to pooled neutrophil RNA from 7 healthy controls.
ORGANISM(S): Homo sapiens 
2005-01-09 | E-GEOD-971 | biostudies-arrayexpress
TranscriptomicsMyeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-M-NM-:B gene network
Chromosome 5q deletions (del(5q)) are common in high-risk (HR) Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML); however, the gene regulatory networks that sustain these aggressive diseases are unknown. Reduced miR-146a expression in del(5q) HR-MDS/AML and miR-146a-/- hematopoietic st...
ORGANISM(S): Homo sapiens 
2014-08-23 | E-GEOD-60649 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of bone marrow cells of MDS patients
Myelodysplastic Syndromes (MDSs) are a heterogeneous family of clonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis and frequently leukemia progression. To exlore how MDS develop into leukemia, we performed the transcriptional profiling of lesional cells and normal...
ORGANISM(S): Homo sapiens 
2009-05-28 | E-GEOD-16236 | biostudies-arrayexpress
TranscriptomicsA gene expression database for retinal neuron subtypes
The goal of this experiment was to define gene expression patterns of thirteen mouse retinal neuron subsets, labeled by expression of fluorescent proteins in transgenic mice. Neurons expressing xFPs were purified by flow cytometry. Thirteen different neuron subtypes were compared. Two biological rep...
ORGANISM(S): Mus musculus 
2012-03-13 | E-GEOD-35077 | biostudies-arrayexpress
TranscriptomicsRNA expression profiles in CD34+ and in stromal cells of patients with refractory anemia with ringed sideroblasts
Myelodysplastic syndromes (MDS) are a group of clonal hematological disorders characterized by ineffective hematopoiesis with morphological evidence of marrow cell dysplasia resulting in peripheral blood cytopenia. Microarray technology has permitted a refined high-throughput mapping of the transcri...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-18911 | biostudies-arrayexpress
TranscriptomicsGenes Differentially Expressed as a result of Candida albicans SC5314 biofilms exposure to 10b
Biomaterial infections are an increasingly alarming problem, and because of their intrinsic recalcitrance to conventional therapy, a new class of antifungal drugs must be explored. 10b, a 2-aminotetralin derivate, was synthesized as a novel chemical structural antifungal agent and exibited strong an...
ORGANISM(S): Candida albicans 
2010-05-18 | E-GEOD-19226 | biostudies-arrayexpress
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