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ModelsLiu2010_Hormonal_Crosstalk_Arabidopsis
This is the single cell model for analysis of hormonal crosstalk in Arabidopsis described in the article: Modelling and experimental analysis of hormonal crosstalk in Arabidopsis. Liu J, Mehdi S, Topping J, Tarkowski P and Lindsey K. Mol Syst Biol. 20...
2024-09-02 | BIOMD0000000269 | BioModels
ProteomicsIdentification of novel pyrazolopyrimidine compounds that modulate the shelterin complex and telomere length regulation via phosphoglycerate kinase 1 and stress sensor DJ1
Telomere signalling and metabolic dysfunction are hallmarks of cell aging, and are associated with a variety of pathologies. Identification of new agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. Here we rep...
ORGANISM(S): Homo sapiens (Human) 
2019-07-19 | PXD011356 | Pride
Trf2 Shelterin Dj1 Pgk1 Telomere Stress 
UnknownCoffee Leaf Rust (Hemileia vastatrix) from the Recent Invasion into Hawaii Shares a Genotypic Relationship with Latin American Populations.
Not available
S-EPMC8877902 | biostudies-literature
UnknownMathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.
Not available
S-EPMC3923661 | biostudies-literature
TranscriptomicsLudwig Institute/UCSD ENCODE project June 2007 Release
The readout of genome information is controlled by transcriptional regulatory elements, but a comprehensive view of the combinatorial control by these DNA sequences, which bind regulatory protein and/or the modified histones in regulating gene transcription, is clearly preliminary. We have developed...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-GEOD-7872 | biostudies-arrayexpress
UnknownA Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation.
Not available
S-EPMC6700475 | biostudies-literature
ProteomicsDevelopmentally regulated sex differences in K48 polyubiquitination in the amygdala
This project examined if sex differences in K48 polyubiquitination in the amygdala were developmentally regulated. This used basolateral amygdala (BLA) samples collected from 4 and 9 week old male and female Sprague-Dawley rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-11-06 | PXD042021 | Pride
Sex differences Amygdala Ubiquitin Ptsd K48 
TranscriptomicsEpigenetic signatures of alcohol abuse and hepatitis infection during hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. Altered DNA methylation landscapes are ubiquitous features of cancer. Interpretation of epigenetic aberrations in HCC is confounded by effects of multiple etiologic drivers and underlying cirrhosis in most cas...
ORGANISM(S): Homo sapiens 
2014-09-16 | E-GEOD-60753 | biostudies-arrayexpress
TranscriptomicsAcute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome [methylation]
Global patterns of DNA methylation, mediated by the DNA methyltransferases (DNMTs), are disrupted in all cancers by mechanisms that remain largely unknown, hampering their development as therapeutic targets. Combinatorial acute depletion of all DNMTs in a pluripotent human tumor cell line, followed ...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-54840 | biostudies-arrayexpress
TranscriptomicsIdentification of an SRF- and androgen-dependent gene signature in prostate cancer
The androgen receptor (AR) is the principal target for treatment of non-organ confined prostate cancer (PCa). Systems and bioinformatics approaches suggest that considerable variation exists in the mechanisms by which AR regulates expression of effector genes and point towards a role for secondary ...
ORGANISM(S): Homo sapiens 
2011-02-28 | E-GEOD-22606 | biostudies-arrayexpress
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