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ProteomicsImmunoprecipitation results against SmD2
We performed immunoprecipitation of SmD2 protein in the HCCLM3 cell line to seek proteins that interact with SmD2 in hepatocellular carcinoma.
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD043535 | Pride
Smd2 Hcclm3 Immunoprecipitation 
ProteomicsCholangiocarcinoma Cell of PDHA1 MS
The discovery of various lysine acylations raises a question as to whether they are subject to dynamic regulation and, if so, by which enzymes. Since acyltransferases play a crucial role in the succinylation process (acyltransferases are responsible for coupling acyl-CoA to non-protein substrates...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060056 | Pride
Pdha1 Ms Cholangiocarcinoma 
MetabolomicsMacrophage-specific BCAT1 deficiency drives lipid-associated immunosuppressive remodeling and promotes HCC progression

The heterogeneous and immunosuppressive tumor microenvironment (TME) remains one of the major factors to the poor immunotherapeutic response in hepatocellular carcinoma (HCC). Tumor-associated macrophages (TAMs) are central orchestrators of this suppressive niche, yet the metabolic programs regul...

2025-12-28 | MTBLS13579 | MetaboLights
MetabolomicsRIOK1 Phase Separation Shapes Stress Adaptation and Cell Fate in Hepatocellular Carcinoma

Cancer cells can always be unexpected rescued from desperate environment by mounting adaptive responses to resolve the arising cellular stress. The dynamic stress granules (SGs) assembly and metabolic reprogramming play crucial roles in maintaining cellular growth and homeostasis. However, the me...

2025-02-26 | MTBLS11963 | MetaboLights
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