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ProteomicsProteomic analysis of the aggregated proteins in cerebral vessles from MYPT1SMKO mice
To comprehensively understand the mechanism by which MYPT1 modulates the phenotypic switching of VSMCs after ischemic stroke, the proteins of cortical small vessel from MYPT1SMKO and WT mice subjected to MCAO or sham group were collected for proteomic screening.
ORGANISM(S): Mus musculus (Mouse) 
2021-08-21 | PXD027869 | Pride
Mypt1 Ischemmic stroke Vsmc Bbb 
ProteomicsInterplay between acetylation and ubiquitination of Isw1 confers multidrug resistance in Cryptococcus neoformans
Lysine acetylation and ubiquitination are one of many protein modifications and play a crucial role in the biological regulation of many organisms, but little is known about the relationship between acetylation and ubiquitination few. Here, the Isw1 protein is an important member of the chromatin re...
ORGANISM(S): Candida albicans (Yeast) 
2022-12-26 | PXD037150 | Pride
Acetylation  ubiquitination  multidrug resistance 
ProteomicsHuman cholangiocarcinoma LC-MS/MS
The glycosylation landscape of Human cholangiocarcinoma (CCA), and how it affects CCA diagnosis and prognosis, has recently emerged as an appealing research field.In this study, we used chemical glycoproteomic analysis Click-iG for systematic profiling of intact glycopeptides in CCA and HIBEpiC cell...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD048188 | Pride
Glycoproteomics Click-ig Cholangiocarcinoma 
ProteomicsVitamin C-induced breast cancer cell death is associated with remodeling the redox state of cysteine-containing proteins involved in translation and cell cycle progression
Recent studies show vitamin C (VitC) pro-oxidant properties at high pharmacological concentrations which favor repurposing VitC as an anti-cancer therapeutic agent. However, redox-based anticancer properties of different forms of VitC are yet partially understood. We examined the difference between ...
ORGANISM(S): Homo sapiens (Human) 
2019-08-16 | PXD013833 | Pride
Breast cancer Ascorbic acid Vitamin c Dehydroascorbic acid Oxidative stress Redoxome 
ProteomicsNovel insights into redox-based mechanisms for auranofin- induced rapid cancer cell death
One of the significant features of cancer cells is a persistent pro-oxidative status. Therefore, compared to their normal counterparts, the malignant cells are generally more dependent on antioxidants for cell survival and more vulnerable to further oxidative insults via pharmacolog-ical interventio...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036558 | Pride
Auranofin  oxidative stress  redox regulation  redoxome  cancer 
ProteomicsProtein phosphorylation networks in Baylisascaris procyonis revealed by phosphoproteomic analysis
Background: Baylisascaris procyonis is an intestinal ascarid worm that parasitizes in raccoons and causes fatal neural, visceral, and ocular larva migrans in humans. Phosphorylated proteins and protein kinases have been studied as vaccine and drug target candidates against parasitic infections. Howe...
ORGANISM(S): Baylisascaris procyonis 
2025-08-04 | PXD066529 | Pride
Raccoon Liquid chromatography-mass spectrometry Signaling pathway Baylisascaris procyonis Phosphoproteome Function 
MetabolomicsPrimary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice with Connexin43 Dominant Negative Mutants

Osteocytes could release some small molecules (≤ 1 kDa) through gap junctions and hemichannels to extracellular environment, such as prostaglandin E2 (PGE2), nitric oxide (NO) and adenosine triphosphate (ATP), which play key roles in transferring signals between bone cells and other tissue cells....

2021-04-14 | MTBLS2358 | MetaboLights
ProteomicsAnalysis of the protein corona on nanoparticles in mouse plasma
We designed three types of nanoparticles with different lipid compositions, each exhibiting distinct tumor accumulation efficiencies. By isolating the protein corona formed on these nanoparticles in mouse plasma, we performed mass spectrometry to characterize the differential protein adsorption prof...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD063915 | Pride
Protein corona Nanoparticle 
MetabolomicsComparative analysis of proteomic and metabolomic profiles of different species of Paris

An extract prepared from species of Paris is the most widely consumed herbal product in China. The genus Paris includes a variety of genotypes with different medicinal component contents but only two are defined as official sources. Closely related species have different medicinal properties beca...

2020-01-13 | MTBLS779 | MetaboLights
MetabolomicsFlavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves
Ginkgo leaves are always resources for flavonoids pharmaceutical industry. However, the effect of the elevation and tree age changes on flavonoid biosynthesis have not been detailly explored in Ginkgo leaves. In addition, whether these environmental pressures have similar effects on the biosynthesis...
2020-12-14 | MTBLS962 | MetaboLights
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