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TranscriptomicsComparison of gene expression between Human umbilical vein endothelial cells and Human liver sinusoidal endothelial cells
To identify leukocyte adhesion receptors which differentially regulate recruitment in human liver sinusoidal endothelial cells compared to a protoptypic venular endothelium Gene expression was measured in four groups Group 1: cultured human liver sinusoidal endothelial cells (HSEC) Group 2: cultured...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-78020 | biostudies-arrayexpress
TranscriptomicsNormal and injured liver sinusoidal endothelial cells
Comparison of C57BL/6J 8-10 weeks male mouse liver sinusoidal endothelial cells (LSEC) from normal liver and from liver injured by carbon tetrachloride administration. Keywords: other
ORGANISM(S): Mus musculus 
2004-10-01 | E-GEOD-1689 | biostudies-arrayexpress
MetabolomicsChemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation

Background: Placental metabolic abnormalities are linked to pregnancy complications such as preeclampsia, gestational diabetes mellitus and fetal growth restriction. However, little is known about how the metabolic processes regulate placental development and trophoblast differentiation. The adip...

2025-06-13 | MTBLS12552 | MetaboLights
ProteomicsLiver sinusoidal endothelial cells constitute a major route for hemoglobin clearance
Mild hemolysis of senescent erythrocytes occurs physiologically in the spleen resulting in Hb release, whereas pathologic erythrocyte rupture characterizes several diseases. Iron recycling from Hb and Hb detoxification have been attributed to the sequestration of Hb-haptoglobin complexes by macropha...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-12 | PXD051274 | Pride
Mouse Liver sinusoidal endothelial cells Hemoglobin clearance 
ProteomicsChanges in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone
Liver sinusoidal endothelial cells (LSECs) are specialized fenestrated scavenger endothelial cells involved in the elimination of modified plasma proteins and tissue turnover waste macromolecules from blood. LSECs also participate in liver immune responses. A challenge when studying LSEC biology is ...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-09-06 | PXD029241 | Pride
Endothelial activation Cell survival Dexamethasone Glucocorticoid(s) Rat Liver sinusoidal endothelial cell(s) Lc-msms Secretome Scavenger receptors Capillaries Proteomics Tmt isobaric tag labeling Il-1b Liver Proteome Phenotype 
ProteomicsFreshly isolated rat liver sinusoidal endothelial cells and Kupffer cells, LC-MSMS
Liver sinusoidal endothelial cells (LSECs) and Kupffer cells (KCs) have important roles in liver homeostasis and host defense. Sharing the same microenvironment in the liver sinusoid, they form an effective scavenger cell system for removal of potentially harmful blood-borne substances. Unlike most ...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-11-11 | PXD012080 | Pride
Liver cells Macrophage Rat Immunity Endothelium 
TranscriptomicsA single cell transcriptome atlas of murine endothelial cells
The heterogeneity of endothelial cells (ECs), lining blood vessels, across tissues remains incompletely inventoried. We constructed an atlas of >32,000 single-EC transcriptomic data from 11 tissues of the model organism Mus musculus. We propose a new classification of EC phenotypes based on transcri...
ORGANISM(S): Mus musculus 
2020-02-13 | E-MTAB-8077 | biostudies-arrayexpress
TranscriptomicsEffect of splenectomy on liver sinusoidal cells after 70% liver resection in a mouse model
In this work, the effect of splenectomy on liver sinusoidal cells was studied. For this purpose in the animals were reproduced splenectomy, and after 7 days 70% liver resection was performed. Animals in which the spleen was intact and only 70% liver resection was performed served as a comparison gr...
ORGANISM(S): Mus musculus 
2025-03-18 | E-MTAB-14941 | biostudies-arrayexpress
TranscriptomicsTranscriptome of human liver cells and culture-activated hepatic stellate cells
The molecular determinants of a healthy human liver cell phenotype remain largely uncharacterized. In addition, the gene expression changes associated with activation of primary human hepatic stellate cells, a key event during fibrogenesis, remain poorly characterized. Here, we provide the transript...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-68000 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human hepatic cells derived from foreskin fibroblast cell line and from embryonic stem cells.
Reprogrammed somatic cells offer a valuable source of pluripotent cells that have the potential to differentiate into many cells types and provide a new tool for regenerative medicine. In the present study we differentiated induced pluripotent stem cells (iPS cells) into hepatic cells. We first show...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-14897 | biostudies-arrayexpress
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