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ProteomicsThe human cathelicidin antimicrobial peptide LL-37 promotes the growth of the pulmonary pathogen Aspergillus fumigatus.
Aspergillus fumigatus contributes to invasive and allergic pulmonary disease in immunocompromised individuals. The pulmonary mucus of cystic fibrosis (CF) patients displays elevated levels of the pleiotropic cathelicidin antimicrobial peptide LL-37 and the aim of this work was to assess the effect o...
ORGANISM(S): Aspergillus fumigatus var. fumigatus 
2018-05-22 | PXD008143 | Pride
Growth Ll-37 Aspergillus Antimicrobial 
ProteomicsExPEC OmpT LL-37 Cleavage LC-MS
Colicin V (ColV)-like plasmids (ColVLPs) are virulence plasmids frequently carried by extra-intestinal pathogenic E. coli (ExPEC) that cause human and avian infection. ColVLPs encode OmpTp, an outer membrane protease with the capacity to cleave the antimicrobial peptide LL-37, which is expressed in ...
ORGANISM(S): Escherichia coli 
2025-11-21 | PXD060817 | Pride
Ll-37 E coli Expec Ompt 
TranscriptomicsTranscriptional response of Pseudomonas aeruginosa PAO1 to human host defense peptide LL-37
In this experiment the transcriptional response of the opportunistic human pathogen Pseudomonas aeruginosa towards physiological concentrations of the major human host defense peptide LL-37 was investigated using microarrays. To this aim, three independent cultures of P. aeruginosa PAO1 were grown u...
ORGANISM(S): Pseudomonas aeruginosa 
2013-12-20 | E-MEXP-3970 | biostudies-arrayexpress
ProteomicsProteomic adaptation of Streptococcus pneumoniae to the human antimicrobial peptide LL-37
Secreted antimicrobial peptides (AMPs) are an important part of the human innate immune system and prevent local and systemic infections by inhibiting bacterial growth in a concentration dependent manner. In the respiratory tract, the cationic peptide LL-37 is one of the most abundant AMPs and capab...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2020-03-19 | PXD016511 | Pride
Lc-msms Adaptation Antimicrobial peptide Ll-37 Streptococcus pneumoniae 
TranscriptomicsTranscription profiling of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37
The objective of the study was to evaluate transcriptional response of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37. A functional genomics approach was used to establish a temporal transcriptional profile and identify differentially expressed gene...
ORGANISM(S): Homo sapiens 
2006-08-01 | E-FPMI-4 | biostudies-arrayexpress
TranscriptomicsComparative analysis of gene expression in response to LL-37 treatment
To identify the potential LL-37-responsed genes, we treated cells with or without LL-37 and their correspondent transcriptional profiles were compared. Total 104 significant genes were identified. Among them, 70 genes are upregulated in repsonse to LL-37 while 34 genes are downregulated in compariso...
ORGANISM(S): Candida albicans 
2016-03-11 | E-GEOD-45177 | biostudies-arrayexpress
GenomicsLL-37 inhibits EV71 infection by upregulating STAC
LL-37 inhibits EV71 infection by upregulating STAC
PRJNA1370898 | ENA
TranscriptomicsTranscriptional profiling of THP-1 cells on treatment with LL-37 and nano conjugated LL-37
Gene expression in THP-1 cells treated for 6 hours with CNT and GNP conjugated with LL-37, LL-37 spiked as well as free LL-37: Reference (Total RNA Mixture of all samples) vs. treated cells
ORGANISM(S): Homo sapiens 
2017-06-17 | GSE98630 | GEO
TranscriptomicsLL-37 inhibits EV71 infection by upregulating STAC
LL-37, a 37-amino acid human-derived antimicrobial peptide, exhibits antiviral functions against multiple enveloped and non-enveloped viruses. We here report that the expression of the Stac is upregulated by LL-37 regardless of EV71 infection in Caco-2 colorectal adenocarcinoma cells. The treatment ...
ORGANISM(S): Homo sapiens 
2026-05-14 | GSE311775 | GEO
TranscriptomicsComparative analysis of gene expression in response to LL-37 treatment
To identify the potential LL-37-responsed genes, we treated cells with or without LL-37 and their correspondent transcriptional profiles were compared. Total 104 significant genes were identified. Among them, 70 genes are upregulated in repsonse to LL-37 while 34 genes are downregulated in compariso...
ORGANISM(S): Candida albicans 
2016-03-11 | GSE45177 | GEO
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