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TranscriptomicsTranscription profiling of human soluble guanylate cyclase-deficient U937 cells exposed to the nitric oxide (NO) donor S-nitrosoglutathione to provide insight into the cGMP-independent effects of NO
NO effects on gene expression, independent of cGMP, were examined globally. Differentiated human U937 cells that lack soluble guanylate cyclase were exposed to Snitrosoglutathione, a NO donor, or glutathione without or with dibutyryl-cAMP (Bt2cAMP). NO regulated 110 transcripts that annotated dispro...
ORGANISM(S): Homo sapiens 
2007-09-11 | E-GEOD-2649 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocytes reveals leukotriene D4 induces gene expression through cysteinyl leukotriene type I receptor.
Background: Cysteinyl leukotrienes (cysLTs) are important mediators of innate immune responsiveness and chronic inflammatory diseases. CysLTs acting through cysteinyl leukotriene receptors may influence the migration and activity of cells such as eosinophils, monocytes and dendritic cells. Objective...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7807 | biostudies-arrayexpress
UnknownLeukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor.
Not available
S-EPMC5560436 | biostudies-literature
UnknownTemporal Changes in Microrna Expression in Blood Leukocytes from Patients with the Acute Respiratory Distress Syndrome.
Not available
S-EPMC5432391 | biostudies-literature
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells, or whole blood were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge vs controls
Peripheral blood mononuclear cells were isolated 0, 30 min, 6 h, 24 h, and 7 day after intravenous endotoxin challenge using cell preparation tubes (Vacutainer® CPT). The PBMC layer was lysed with RLT buffer, homogenized, and then stored at –80°C. Total RNA was extracted as per RNeasy‚ Midi protocol...
ORGANISM(S): Homo sapiens 
2007-12-19 | E-GEOD-3026 | biostudies-arrayexpress
TranscriptomicsImmune Responses to Pneumocystis Infection are Robust in Immunocompetent Mice but Absent in CD40 Ligand Deficient Mice
Pneumocystis is a pathogen of immunocompromised hosts but can also infect healthy hosts, in whom infection is rapidly controlled and cleared. To better understand the immune mechanisms contributing to clearance of infection, microarray methods were used to examine differential gene expression in the...
ORGANISM(S): Mus musculus 
2008-12-22 | E-GEOD-11005 | biostudies-arrayexpress
UnknownCytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.
Not available
S-EPMC2519846 | biostudies-literature
UnknownActivation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium.
Not available
S-EPMC5130531 | biostudies-literature
TranscriptomicsCooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes
LTB4, 50 nmol/L for 30 minutes, induced expression of 27 genes in cultured human elutriated monocytes comparred to vehicle (ethanol) treated control cells. Matched control versus treated cells
ORGANISM(S): Homo sapiens 
2011-09-20 | E-GEOD-24869 | biostudies-arrayexpress
UnknownValidation of normal human bronchial epithelial cells as a model for influenza A infections in human distal trachea.
Not available
S-EPMC4409941 | biostudies-literature
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