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ProteomicsGlobal phosphoproteomic profiling of skeletal muscle in ovarian-hormone deficient mice
Phosphorylation is important in skeletal muscle development, growth, regeneration, and contractile function. Alterations in the skeletal muscle phosphoproteome due to aging have been reported in males; however, studies in females are lacking. We have demonstrated that estrogen deficiency decreases m...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-28 | PXD035107 | Pride
Estrogen Females Sarcomere Ovariectomy Myozenin-2 Tropomyosin Obscurin Myosin heavy chain-2 And calcium signaling 
ProteomicsNatural aging and ovariectomy induces parallel phosphoproteomic alterations in skeletal muscle of female mice
The loss of skeletal muscle strength mid-life in females is associated with the decline of estrogen. Here, we questioned how estrogen deficiency might impact the overall skeletal muscle phosphoproteome after contraction, as force production induces phosphorylation of several muscle proteins. Phospho...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-01 | PXD035171 | Pride
Ovariectomy Female And aging 
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