Sort   by:  
 Page size 
ProteomicsDynamics of an LPS translocon induced by substrate and an antimicrobial peptide
We investigated the conformational dynamics of the LPS translocon LptDE was using hydrogen-deuterium exchange mass spectrometry. We evaluated the conformational changes of LptDE upon binding of LPS, Re-LPS (an LPS substructure), thanatin, and the membrane lipid POPG. Our data reveal that LPS induces...
ORGANISM(S): Klebsiella pneumoniae 
2020-11-16 | PXD021743 | Pride
Lps Hydrogen-deuterium exchange Hdx-ms Thanatin Lptde 
ProteomicsStructural basis of gate dynamics at the outer membrane lipopolysaccharide holo-translocon
Gram-negative bacteria resist many harmful chemicals, protected by an asymmetric outer membrane (OM) containing lipopolysaccharide (LPS) in its external leaflet. Leaflet-selective assembly of LPS is an essential, yet mechanistically elusive process. This reaction is mediated by the OM LPS core trans...
ORGANISM(S): Escherichia coli 
2025-12-01 | PXD068376 | Pride
Lps translocon Native ms Gel digestion 
Proteomics• Optimal Functioning of the Lipopolysaccharide Transport Bridge Depends on a Ternary Complex Between the Lipocalin YedD and the LptDE Translocon
The outer membrane is an efficient permeability barrier that protects Gram-negative bacteria against external assaults including many antibiotics. The unique permeability features of the outer membrane are due to the presence of lipopolysaccharide (LPS) molecules in its outer leaflet. LPS localizati...
ORGANISM(S): Escherichia coli 
2025-07-09 | PXD059551 | Pride
Lps Bacteria Lipocalin Outer membrane Translocon 
ProteomicsLptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry.
Insertion of lipopolysaccharide (LPS) into the outer membrane (OM) of Gram-negative bacteria is mediated by a druggable OM translocon consisting of a beta-barrel membrane protein, LptD, and a lipoprotein, LptE. The beta-barrel assembly machinery (BAM) assembles LptD together with LptE to form a plug...
ORGANISM(S): Escherichia coli 
2023-10-11 | PXD041774 | Pride
Lptde Native ms Hdx-ms Membrane protein Translocon 
UnknownStructural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex.
Not available
S-EPMC12644819 | biostudies-literature
UnknownLptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry.
Not available
S-EPMC10567701 | biostudies-literature
UnknownDynamics of an LPS translocon induced by substrate and an antimicrobial peptide.
Not available
S-EPMC7116625 | biostudies-literature
UnknownOuter Membrane Translocon Communicates with Inner Membrane ATPase To Stop Lipopolysaccharide Transport.
Not available
S-EPMC6200140 | biostudies-literature
UnknownLptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface.
Not available
S-EPMC4084488 | biostudies-literature
ProteomicsEffect of Sec61 inhibitor mycolactone on the proteome of the MED17.11 neuronal cell line
Mycolactone is a mycobacteria-derived macrolide that blocks the biogenesis of a large array of secreted and transmembrane proteins through potent inhibition of the Sec61 translocon. Here, we used quantitative proteomics to delineate the direct and indirect effects of mycolactone-mediated Sec61 block...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-26 | PXD007770 | Pride
Sec61 Mycolactone Sensory neurons 
Sort   by:  
 Page size