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ProteomicsArsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells
Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) combination safely cures fatal acute promyelocytic leukemia, but the mechanisms underlying their action and synergy remain elusive. ATRA inhibits APL, breast and liver cancers by targeting isomerase Pin1, a master regulator of oncogenic signa...
ORGANISM(S): Homo sapiens (Human) 
2018-10-16 | PXD010224 | Pride
Ato Atra Synergy Pin1 
ProteomicsMosaic PKHD1 variants in polycystic kidney caused aberrant protein profiling of mitochondria and lysosomes
Autosomal recessive polycystic kidney disease (ARPKD) is a severe renal cystic disease mainly caused by PKHD1. However, its genetic cause, pathological features, and mechanism remained unsolved. Our findings may provide new insight on the pathophysiology of the polycystic kidney due to PKHD1 deficie...
ORGANISM(S): Homo Sapiens 
2021-08-20 | PXD028042 |
ProteomicsQuantitiave analysis of protein methylome reveals the cellular response to ionizing radiation
Protein methylation plays important roles in DNA damage signaling. To date, there is still a lack of global profiling of whole-cell methylation changes during the DNA damage response and repair. In this study, using HILIC affinity enrichment combined with MS analysis, we conducted a quantitative ana...
ORGANISM(S): Homo Sapiens 
2022-02-14 | PXD031655 |
ProteomicsIdentifying the patients with rapid progression from hormone-sensitive to castration-resistant prostate cancer
We collected 78 biopsies and analyzed the proteomic expression by pressure cycling technology and Pulsed data-independent acquisition (PCT-PulseDIA) pipeline. Next, we explore the differentially expressed proteins (DEPs) in the discovery set (n=16) which contains short (S, n=8)- and long (L, n=8)- t...
ORGANISM(S): Homo Sapiens 
2022-11-04 | PXD037951 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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