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MetabolomicsMono-Locus and Pyramided Resistant Grapevine Cultivars Reveal Early Putative Biomarkers Upon Artificial Inoculation With Plasmopara viticola
One of the most economically important grapevine diseases is Downy mildew (DM) caused by the oomycete Plasmopara viticola. A strategy to reduce the use of fungicides to compensate for the high susceptibility of V. vinifera is the selection of grapevine varieties showing pathogen-specif...
2021-07-07 | MTBLS2876 | MetaboLights
ProteomicsUncovering biological heterogeneity in endometrial carcinoma molecular subtypes by proteomic analysis
While endometrial cancer (EC) has an overall favorable prognosis, some patients do poorly and may benefit from refinements of current classification systems. Molecular classification stratifies ECs into four prognostic groups: POLEmut, MMRd (mismatch repair deficient), p53abn, and NSMP (no specific ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD057700 | Pride
Ffpe Endometrial carcinoma Tmt 
ProteomicsMultiomics Characterization of Potential Therapeutic Vulnerabilities in Low-grade Serous Ovarian Carcinoma
Fourteen LGSOC cell lines were interrogated using whole exome sequencing, RNA sequencing, and mass spectrometry-based proteomics. Somatic mutation, copy-number aberrations, gene and protein expression were analyzed and integrated using different computational approaches. LGSOC cell line data was com...
ORGANISM(S): Homo sapiens (Human) 
2021-05-17 | PXD019544 | Pride
Tmt Ovarian carcinoma 
ProteomicsRe-expression of SMARCA4/BRG1 in Small Cell Carcinoma of Ovary, Hypercalcemic Type (SCCOHT) promotes an epithelial-like gene signature through an AP-1-dependent mechanism
Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer. SCCOHT tumors have inactivating mutations in SMARCA4 (BRG1), one of the two mutually exclusive ATPases of the SWI/SNF chromatin remodeling complex. To address the role that BRG1 loss plays...
ORGANISM(S): Homo sapiens (Human) 
2021-01-15 | PXD014134 | Pride
Ovarian carcinoma smarca4 
ProteomicsChanges in the tumor microenvironment mark transition from serous borderline tumor to low grade serous carcinoma
Low grade serous ovarian cancer (LGSC) is a rare subtype of ovarian cancer, characterized by a slow growth rate, resistance to current treatment regimens, multiple recurrences and poor survival. LGSC arise from serous borderline tumor (SBT), however the mechanism of transformation is poorly understo...
ORGANISM(S): Homo sapiens (Human) 
2024-08-15 | PXD046360 | Pride
Tmt Ovarian cancer Serous borderline tumor 
ProteomicsA comprehensive evaluation of the Ewing sarcoma surface and global proteomes reveals actionable immunotherapeutic targets.
Ewing sarcoma (EwS) is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. While the survival rate of patients diagnosed with localized disease is ~70%, this decreases to ~30% for patients with metastatic disease and only ~10% for treatment refractory d...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD043375 | Pride
Ewing sarcoma Surfaceome 
ProteomicsHexameric VCP/p97 reprograms transcription by organizing enhancers with the ASPSCR1-TFE3 fusion oncoprotein
Aberrant transcription in alveolar soft part sarcoma (ASPS) is orchestrated by the fusion oncoprotein, ASPSCR1-TFE3, resulting from a gene fusion created by a t(X;17) chromosomal translocation. Proteomic analysis of co-immunoprecipitated ASPSCR1-TFE3 complexes revealed strong enrichment of VCP/p97, ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-11-23 | PXD022515 | Pride
Asps Ip-ms Tmt 
ProteomicsSurface and global proteome profiling of osteosarcoma patient derived xenografts
This study analyzed 22 unique OS patient-derived xenografts (PDXs) using proteomics to identify surface proteins for potential immunotherapeutic targeting. Plasma membranes were enriched using density gradient ultracentrifugation and compared to a reference standard of 12 immortalized non-OS cell li...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD075484 | Pride
Osteosarcoma 
ProteomicsGlobal proteome analysis of shROR2 MNNG cells
MNNG cells expressing a doxycycline (DOX)-inducible non-targeting shRNA (shCTRL) construct, or three independent shRNA constructs targeting ROR2 (shROR2 1, shROR2 2 and shROR2 3), were grown for 7 days in the presence of 5 µg/ml DOX prior to extraction.
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD077022 | Pride
Ror2 Osteosarcoma 
ProteomicsThe proteome of clear cell ovarian carcinoma
Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late stage CCOC is not responsive to gold-standard chemotherapy and result in suboptimal outcome for patients. In-depth molecular insight is urgently needed to stratify the disease and drive therap...
ORGANISM(S): Homo sapiens (Human) 
2022-09-02 | PXD032355 | Pride
Ovarian carcinoma Tmt Clear cell 
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