Sort   by:  
 Page size 
ProteomicsIntegrating serum protein electrophoresis with mass spectrometry, a new workflow for M-protein detection and quantification
Serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) are standard tools for multiple myeloma (MM) routine diagnostics. M-protein is a biomarker for MM that can be quantified with SPE and characterized with IFE. We have investigated combining SPE/IFE with targeted mass spectro...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD016325 | Pride
Serum protein electrophoresis Immunofixation electrophoresis Targeted mass spectrometry Multiple myeloma M-protein 
ProteomicsIdentification of a collagen marker in urine improves the detection of colorectal liver metastases
Previously, we reported that a combination of a collagen alpha-1(I) natural occurring peptide (NOP) AGPP(-OH)GEAGKP(-OH)GEQGVP(-OH)GDLGAP(-OH)GP (AGP) and serum carcinoembryonic antigen (CEA) has the potential to detect colorectal liver metastases (CRLM). The combined method needs to be adapted to i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-15 | PXD013533 | Pride
Logistic regression model Colon cancer Colorectal cancer Prm Collagen Colorectal liver metastases Mass spectrometry Natural occurring peptides Urine 
ProteomicsT Lymphocytes induce the expression of Coronin-1A in breast cancer cells enabling the transmigration through a blood-brain-barrier model
Background: In previous work we discovered that T lymphocytes play a prominent role in the rise of brain metastases of ER-negative breast cancers. In the present study we explored expressional changes due to T cell contact associated with penetration through the BBB for breast cancer cell lines deri...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD053787 | Pride
Breast cancer  brain metastasis  blood-brain barrier  proteomics  liquid chromatography-mass spectrometry  coronin-1a 
ProteomicsT cells facilitate brain metastasis of breast cancer.
Three breast cancer cell lines were co-cultured with T cells isolated from normal donors, in 3: 1 ratio. As controls, the breast cancer cells were cultured without T cells for three days. All cell cultures were washed three times with PBS to remove T cells before they were scraped and collected in 1...
ORGANISM(S): Homo sapiens (Human) 
2018-01-24 | PXD006750 | Pride
Breast cancer T cell response Human. Brain metastasis 
UnknownMonitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients with Multiple Myeloma.
Not available
S-EPMC11769374 | biostudies-literature
UnknownM-protein diagnostics in multiple myeloma patients using ultra-sensitive targeted mass spectrometry and an off-the-shelf calibrator.
Not available
S-EPMC10808047 | biostudies-literature
ProteomicsDynamic monitoring of myeloma minimal residual disease with targeted mass spectrometry
Serum samples from multiple myeloma (MM) patients are collected regularly for conventional tests to quantify the M-protein longitudinally. However, the limited sensitivity of conventional tests makes quantification of minimal residual disease (MRD) difficult. MRD can be quantified with highly sensit...
ORGANISM(S): Homo Sapiens 
2023-02-27 | PXD038370 | panorama
ProteomicsAutologous Dendritic Cells Loaded with Allogenic Tumor Lysate for Surgically Resected Pancreatic Cancer Patients. Rationale and Clinical Results of a Phase II Study (REACtiVe Trial)
Determination of shared antigens in Pancreatic ductal adenocarcinoma (PDAC) tumor lysate and the allogeneic tumor drug product. The list of tumor antigenes was thereby dervied from preceeding RNA and literature research (e.g. [Cheevers et al 2009](https://europepmc.org/article/MED/19723653)).
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD025210 | Pride
Dendritic cells Immunotherapy T cells Pancreatic adenocarcinoma 
UnknownT lymphocytes facilitate brain metastasis of breast cancer by inducing Guanylate-Binding Protein 1 expression.
Not available
S-EPMC5978929 | biostudies-literature
ProteomicsImproved detection of tryptic immunoglobulin variable region peptides by chromatographic and gas-phase fractionation techniques.
Circulating antibodies provide valuable information about an individual’s immune status and constitute a significant portion of the human plasma proteome. Proteomic analysis of plasma is challenged by the large dynamic concentration range of plasma proteins, including antibodies. Peptide fractionati...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD046072 | Pride
Peptide fractionation Antibody Mass spectrometry Immune repertoire Multi-dimensional chromatography Ion-mobility Bottom-up proteomics De novo sequencing Plasma proteomics 
Sort   by:  
 Page size