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TranscriptomicsOpen lung approach with low tidal volume mechanical ventilation attenuates lung injury in rats with massive brain damage
Introduction: The ideal ventilation strategy for patients with massive brain damage requires better elucidation. We hypothesized that in the presence of massive brain injury, a ventilation strategy using low (6 mL/kg) tidal volume (VT) ventilation with open lung positive end-expiratory pressure set ...
ORGANISM(S): Rattus norvegicus 
2014-04-24 | E-GEOD-52142 | biostudies-arrayexpress
TranscriptomicsVALIDATION STUDY TO VERIFY DIAGNOSTIC MARKERS FOR LUNG CANCER IN ENDOBRONCHIAL LINING FLUID
We investigated whether biomarker analysis in endobronchial epithelial lining fluid (ELF) collected by bronchoscopic microsampling may be useful for a definitive preoperative diagnosis. Therefore we compared ELF samples close to nodule and from the contralateral site from patients with malignant or ...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-27553 | biostudies-arrayexpress
MetabolomicsAirway metabolic profiling during Streptococcus pneumoniae infection identifies branched chain amino acids as signatures of upper airway colonisation

Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and bacteraemia and is capable of remarkable phenotypic plasticity, responding rapidly to environmental change. Pneumococcus is a nasopharyngeal commensal, but is responsible for severe, acute infections followin...

2023-08-08 | MTBLS4591 | MetaboLights
ProteomicsStromal Changes in The Aged Lung Induce an Emergence From Melanoma Dormancy
Disseminated cancer cells (DCCs) that escape the primary site can seed in distal tissues, but may take several years, or even decades to grow out into overt metastases, a phenomenon termed tumor dormancy. Despite its importance in metastasis and residual disease, few studies have been able to succes...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-03 | MSV000088977 | MassIVE
ProteomicsActivity-based SWATH/DIA proteomic screen enables sensitive differential detection of serine hydrolases from surgically resected OCT-embedded primary lung adenocarcinoma
Lung malignancies are among the leading causes of cancer-related death in the modern world. While the disease is relatively manageable if caught at an early stage, the genomic variability and high level of mutations represent a daunting challenge for diagnosis, staging and prognostic classification....
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD019357 | Pride
Abpp Lung adenocarcinoma tissue Swath-ms 
TranscriptomicsSOX2 overexpression effect on human lung squamous cells
We have identified SOX2 as a new oncogene and a likely driver of recurrent 3q26.3 amplifications in lung Squamous Cell Carcinoma. SOX2 is a crucial transcription factor implicated in Embryonic and Neural Stem Cells, that we found widely activatd in human lung SCC. This part of the study aimed at an...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14883 | biostudies-arrayexpress
ProteomicsSpatial resolution of proteomic changes in lung tissue from a flexible AAV-DTR/DT mouse model of acute cell deletion mimicking epithelial lung injury
Lung epithelial injury leads to different pathologies, all associated with severe outcome and increased mortality. These pathologies are divided into chronic and acute diseases like idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) or the acute lung distress syndrome ...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-30 | PXD025712 | Pride
Laser-capture microdissection Tmt Diphtheria toxin Ffpe Aav Dtr Epithelial cells 
TranscriptomicsTranscription profiling of human primary lung adenocarcinomas
We have investigated whether the early dissemination of tumor cells into bone marrow is associated with a specific molecular pattern in primary lung cancer Experiment Overall Design: two groups of primary lung adenocarcinomas were compared differentiating in the metastatic potential
ORGANISM(S): Homo sapiens 
2009-03-14 | E-GEOD-10799 | biostudies-arrayexpress
TranscriptomicsArrayCGH mapping of chromosome 3 aberrations in lung Squamous Cell Carcinoma (SCC)
To prospectively identify new oncogenes implicated in lung Squamous Cell Carcinoma pathogenesis, we investigated chromosome 3 aberrations in advanced tumours using arrayCGH. These aberrations are indeed among the most frequent aberrations in lung SCC and correlate with SCC patient's poor prognosis. ...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-14859 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics (Visium, 10x Genomics) data for human Idiopathic Pulmonary Fibrosis (IPF) and control lung tissue
Visium (10x Genomics) spatially resolved transcriptomics data generated from normal and Idiopathic Pulmonary Fibrosis (IPF) lung parenchyma tissues collected from human donors. The fresh-frozen tissues that were analyzed were from four healthy control (HC) subjects and from four IPF patients. For ea...
ORGANISM(S): Homo sapiens 
2024-05-28 | E-MTAB-14121 | biostudies-arrayexpress
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