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MetabolomicsDistinct metabolic profiles in lung adenocarcinomas presenting as solid or ground-glass opacities

Metabolomic profiling provides real-time insights into tissue physiology and upstream molecular events. Despite its potential in cancer research, large-scale integrative studies in lung adenocarcinoma (LUAD) remain scarce. We analyzed 262 tissue samples from 165 LUAD patients using metabolomic, t...

2025-12-23 | MTBLS13565 | MetaboLights
TranscriptomicsRNA-seq comparison of fetal lung and cultured fetal lung derived organoids with pluripotent stem cell derived lung organoids
Underdeveloped lungs are the primary cause of death in premature infants, however, little is known about stem and progenitor cell maintenance during human lung development. In this study, we have identified that FGF7, Retinoic Acid and CHIR-99021, a small molecule that inhibits GSK3 to activate Wnt ...
ORGANISM(S): Homo sapiens 
2018-11-17 | E-MTAB-6023 | biostudies-arrayexpress
TranscriptomicsA high-resolution single-cell multiomic atlas of the human fetal lung - Organoid
Individual TFs were overexpressed in fetal lung tip organoids from a doxycycline-inducible construct for 3 days, and organoids were maintained in the self-renewing (tip cell-promoting) medium throughout to rigorously assay the lineage-determining competence of the TF, followed by scRNA-seq. ASCL1, ...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11267 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of iPSC-derived lung organoid models
Here, we used single cell RNA sequencing of iPSC17 WT 7B2-derived day 10 lung spheroids, unsorted 3-, 6-, and 10-week lung progenitor organoids (LPOs) and induced bud tip progenitor organoids (iBTOs) sorted from 4- and 10-week LPOs, sequenced 4 weeks post-sort. All cultures were grown in serum-free ...
ORGANISM(S): Homo sapiens 
2022-07-24 | E-MTAB-11953 | biostudies-arrayexpress
TranscriptomicsSingle-nucleus RNA sequencing of positional airway organoids derived from human fetal lung at 4 anatomic regions (trachea, bronchus, NCA, distal)
We derived primary, epithelial-enriched organoids from 120 PCD human fetal lung, specifically from trachea, bronchus, non-cartilaginous airway, and distal airway. These positional airway organoids were grown in FANY airway media for the duration of 2 passages before collection for single-nucleus RNA...
ORGANISM(S): Homo sapiens 
2025-08-01 | E-MTAB-14961 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of CellTagging lung organoids
Here, we used a lentiviral-based barcoding method (CellTagging) to lineage trace progenitor cells in a human lung organoid model. 21-day cultures were transduced for 7 days, fluorescence activated cell sorted for GFP+ expression, and regrown as sparsely plated cells for additional 30 days before seq...
ORGANISM(S): Homo sapiens 
2023-04-21 | E-MTAB-12753 | biostudies-arrayexpress
ProteomicsProteomic Analysis of Patient-Derived Lung Tumoroids and Matched Organoids Compared to Parental Tumors and Tissues
Proteomic characterization of patient-derived lung tumoroids and matched healthy lung organoids compared to their parental tumor and healthy lung tissues from NSCLC patients. The study validates that tumoroids preserve tumor-specific proteomic signatures and identifies proteomic signatures potential...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD070147 | Pride
Lc-msms Nsclc Dia-pasef Car t cells Tumoroids 
TranscriptomicsTranscriptional characterization of Human Lung Organoids (HLOs) using RNAseq
Human lung organoids (HLOs) were derived from human embryonic stem cell line H9 NIH registry #0062. Sequencing of HLOs was performed by the UM DNA Sequencing Core, using Illumina Hi-Seq platform and single-end 50 bp reads. The UM Bioinformatics Core downloaded the reads files from the Sequencing Cor...
ORGANISM(S): Homo sapiens 
2015-03-09 | E-MTAB-3339 | biostudies-arrayexpress
TranscriptomicsEpigenomic characterization of patient-derived lung tumoroids using DNA methylation profiling
DNA methylation analysis of patient-derived lung tumoroids and matched healthy organoids demonstrates preservation of tumor-specific epigenomic identity during long-term culture. Tumoroids maintain the methylation landscape of their parental tumors, with samples from the same patient clustering toge...
ORGANISM(S): Homo sapiens 
2025-12-29 | E-MTAB-16020 | biostudies-arrayexpress
ProteomicsUsing patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: a real-world study
Using patient derived lung cancer organoids to predict clinical response and find theraputic mechanisms
ORGANISM(S): Homo Sapiens 
2022-09-26 | PXD037076 |
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