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ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081704 | MassIVE
ProteomicsIntegrated lysine acetylation stoichiometry and proteomics analysis in human cells
Lysine acetylation is a widespread posttranslational modification that targets a large number of biological pathways. Recent studies reveal that lysine acetylation sites exhibit mainly low stoichiometry. Here we explored three sample preparation methods, the use of detergents for the chemical acetyl...
ORGANISM(S): Homo sapiens (Human) 
2017-09-12 | PXD005903 | Pride
Deacetylase inhibitor Sirt1 Cancer cells Lysine acetylation Stoichiometry Proteomics 
ProteomicsAnalysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions
Acetylation is frequently detected on mitochondrial enzymes and the sirtuin deacetylase SIRT3 is thought to regulate metabolism by deacetylating mitochondrial proteins. However, the stoichiometry of acetylation has not been studied and is important for understanding whether SIRT3 regulates or suppre...
ORGANISM(S): Mus musculus (Mouse) 
2015-09-15 | PXD000885 | Pride
Sirt3 Stoichiometry Acetylation Liver 
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080778 | MassIVE
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells, part 2
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080852 | MassIVE
ProteomicsAnalysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
Lysine acetylation is a reversible posttranslational modification that occurs at thousands of sites on human proteins. However, the stoichiometry of acetylation remains poorly characterized, and is important for understanding acetylation-dependent mechanisms of protein regulation. Here we provide ac...
ORGANISM(S): Homo sapiens (Human) 
2019-03-12 | PXD009994 | Pride
Acetylation Acetylome Human Hela Stoichiometry 
ProteomicsRubisco acetylation stoichiometry in Arabidopsis Thaliana
Multiple studies have shown Rubisco to be subject to Lys-acetylation at various residues; however, conflicting reports exist about the biological significance of these post-translational modifications. One aspect of the Lys-acetylation that has not been addressed in plants generally, or with Rubisco...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-09-28 | PXD019268 | Pride
Lys-acetylation Arabidopsis Rubisco 
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells, part 2
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo sapiens (Human) 
2016-12-24 | PXD004995 | Pride
Lysine acetylation Aspirin Hela 
ProteomicsAccurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome
We applied SD-SILAC to determine absolute acetylation stoichiometry in exponentially-growing and stationary-phase wild type and sirtuin deacetylase CobB-deficient E. coli. We further assayed stoichiometry in phophotransacetylase (pta) and acetate kinase (ackA) mutant strains in the presence and abse...
ORGANISM(S): Escherichia coli 
2017-03-07 | PXD005757 | Pride
E. coli Sirtuin Acetylation Stoichiometry Cobb 
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo sapiens (Human) 
2017-01-10 | PXD003530 | Pride
Lysine acetylation Aspirin Hela 
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