Sort   by:  
 Page size 
TranscriptomicsAneuploidy-induced cellular stresses limit autophagic degradation.
An unbalanced karyotype, a condition known as aneuploidy, has a profound impact on cellular physiology and is a hallmark of cancer. Determining how aneuploidy affects cells is thus critical to understanding tumorigenesis. Here we show that aneuploidy interferes with the degradation of autophagosomes...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-60570 | biostudies-arrayexpress
GenomicsA lysosomal delivery mechanism required for autophagosome degradation
A lysosomal delivery mechanism required for autophagosome degradation
PRJEB62651 | ENA
ProteomicsLysosomal proteomics reveals mechanisms of neuronal apoE4 - 2 associated lysosomal dysfunction
The E4 variant of APOE is the primary risk factor for Alzheimer’s Disease. While APOE is primarily expressed by astrocytes, early AD pathology appears predominantly in neurons, including endosomal abnormalities and mitochondrial dysfunction. Lysosomes are poised at the convergence point between thes...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD044942 | Pride
Lgals3bp Apms Mass spectrometry Apoe 4 Alzheimer’s disease Lysosomes 
UnknownLysosomal activity depends on TRPML1-mediated Ca<sup>2+</sup> release coupled to incoming vesicle fusions.
Not available
S-EPMC11599452 | biostudies-literature
ProteomicsLC-MS/MS analysis of soluble lysosomal enzymes
Mucolipidosis III gamma (MLIII) is clinically characterized by onset of first symptoms at an average of 5 years such as stiffness of hands and shoulders, claw hand deformities, scoliosis and progressive destruction of hip joints. The disease is caused by mutations in GNPTG encoding the gamma-subunit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-07 | PXD007547 | Pride
Mucolipidosis Lysosomal proteomics 
GenomicsLysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
Lysosomal RNA profiling reveals targeting of specific types of RNAs for degradation
PRJNA1260976 | ENA
TranscriptomicsDistinct Protein Degradation Induced by Different Disuse Models of Skeletal Muscle Atrophy
Skeletal muscle atrophy is a consequence of many diseases, environmental insults, inactivity, age and injury. Atrophy is characterized by active degradation and removal of contractile proteins and a reduction in fiber size. Animal models have been extensively used to identify pathways leading to a...
ORGANISM(S): Mus musculus 
2011-10-24 | E-GEOD-25908 | biostudies-arrayexpress
GenomicsmTORC1 feedback to AKT modulates MiT/TFE-driven lysosomal biogenesis and EGFR degradation
mTORC1 feedback to AKT modulates MiT/TFE-driven lysosomal biogenesis and EGFR degradation
PRJNA513331 | ENA
TranscriptomicsTranscription profiling of human CD3-positive T cells from SLE and controls reveals activation of mTOR controls the loss of TCRI? in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation
CD3-positive T cells were negatively isolated from 10 SLE patients and 9 healthy controls without SLE. All of the SLE samples and control samples were compared with one another to identify baseline differences in expression due to the disease. Next, T cell preparations from 4 of the control subjec...
ORGANISM(S): Homo sapiens 
2009-02-28 | E-GEOD-13887 | biostudies-arrayexpress
ProteomicsDisruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson's disease model.
Supporting data for "Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model", DOI: T.B.D. Related to Figure 4A and S4A-B. KN43-66 - TMTpro | 4plex | Whole cell proteome - MS3 KN67-72 - TMTpro | 4plex | Enriched Phospho-peptides - MS2 K...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-24 | MSV000090202 | MassIVE
Sort   by:  
 Page size