Sort   by:  
 Page size 
MetabolomicsRepair-Associated Macrophages Increase after Early-phase Microglia Attenuation to Promote Ischemic Stroke Recovery

Ischemic stroke recovery involves dynamic interactions between the central nervous system and infiltrating immune cells. Peripheral immune cells compete with resident microglia for spatial niches in the brain, but how modulating this balance affects recovery remains unclear. Here, we use PLX5622 ...

2025-02-20 | MTBLS12240 | MetaboLights
ProteomicsProteins enriched on damaged lysosomes in 293T
Lysosomal membrane permeabilization (LMP) or lysosomal membrane damage is commonly associated with aging and age-related diseases. In searching for cellular mechanisms in response to LMP, we used a proteomic approach to identify proteins enriched on damaged lysosomes. This unbiased approach identifi...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD028852 | Pride
Human Lysosomal membrane permeabilization 
MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
ProteomicsProteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease
Aging is the most prominent risk factor for Alzheimer's disease (AD). However, the cellular mechanisms linking neuronal proteostasis decline to the characteristic aberrant protein deposits in AD brains remain elusive. Here, we develop transdifferentiated neurons (tNeurons) from 5 human dermal fibrob...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD059089 | Pride
Proteostasis Lysosome Alzheimer Neurons 
UnknownA phosphoinositide signalling pathway mediates rapid lysosomal repair.
Not available
S-EPMC9450835 | biostudies-literature
UnknownGalectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal.
Not available
S-EPMC6997950 | biostudies-literature
UnknownProteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
Not available
S-EPMC10081252 | biostudies-literature
UnknownDefective lysosomal exocytosis and plasma membrane repair in Chediak-Higashi/beige cells.
Not available
S-EPMC534728 | biostudies-literature
UnknownProteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer's disease.
Not available
S-EPMC11991917 | biostudies-literature
ProteomicsATG9A TurboID - ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair
Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving ER-lysosome membrane contact sites, phosphatidylinositol 4-kinase-2a (PI4K2A), phosphatidylinositol-4 phosphate (PI4P) and oxysterol-binding protein-related proteins (ORPs) li...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD056417 | Pride
Arfip2 Membrane trafficking Autophagy Lysosomal damage Lysosome Ap-3 Pi4k2a Atg9a Pi4p 
Sort   by:  
 Page size