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MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
GenomicsLipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging
Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging
PRJNA1511267 | ENA
GenomicsLASER couples damage sensing to ESCRT assembly for lysosome repair
LASER couples damage sensing to ESCRT assembly for lysosome repair
PRJNA1455520 | ENA
UnknownCholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair.
Not available
S-EPMC9753466 | biostudies-literature
UnknownESCRT-mediated lysosome repair precedes lysophagy and promotes cell survival.
Not available
S-EPMC6213280 | biostudies-literature
TranscriptomicsLipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging
Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. In the retinal pigment epithelium (RPE), lipid dysregulation is strongly associated with aging and ag...
ORGANISM(S): Mus musculus 
2026-09-17 | GSE343357 | GEO
UnknownAnnexin A7 mediates lysosome repair independently of ESCRT-III.
Not available
S-EPMC10860759 | biostudies-literature
ProteomicsVPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are frequently linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...
ORGANISM(S): Homo sapiens (Human) 
2026-07-13 | PXD069825 | Pride
Human Lysosomal repair Vps13c Lysosome purification 
UnknownAge-Driven Lipid Remodeling Activates Lysosome-Mediated Plasma Membrane Repair.
Not available
S-EPMC12869690 | biostudies-literature
ProteomicsATG9A TurboID - ATG9A and ARFIP2 cooperate to regulate PI4P levels for lysosomal repair
Lysosome damage activates multiple pathways to prevent lysosome-dependent cell death, including a repair mechanism involving ER-lysosome membrane contact sites, phosphatidylinositol 4-kinase-2a (PI4K2A), phosphatidylinositol-4 phosphate (PI4P) and oxysterol-binding protein-related proteins (ORPs) li...
ORGANISM(S): Homo sapiens (Human) 
2025-04-22 | PXD056417 | Pride
Arfip2 Membrane trafficking Autophagy Lysosomal damage Lysosome Ap-3 Pi4k2a Atg9a Pi4p 
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