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TranscriptomicsMycobacterium bovis-BCG vaccination induces a specific pulmonary transcriptome biosignature in mice
In the present study, we applied microarray technology to define a biosignature from the whole genome expression in lung and spleen samples after BCG vaccination and M. bovis infection of BALB/c mice. The aims were two-fold, namely to define biosignatures that could predict vaccine success before ch...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-21149 | biostudies-arrayexpress
MetabolomicsIntegrated Transcriptomic and Metabolomic Analyses Reveal the Antibacterial Mechanism of Isocorydine against Mycobacterium bovis

Mycobacterium bovis, the causative agent of bovine tuberculosis, poses a significant zoonotic threat. This study defines the antibacterial activity and mechanism of the natural alkaloid isocorydine (ICD) against M. bovis using an integrated multi-omics approach. Phenotypic analyses demonstrated t...

2025-12-03 | MTBLS13441 | MetaboLights
TranscriptomicsDissecting the Mycobacterium bovis BCG response to macrophage infection to identify targets for anti-tuberculosis drug and vaccine discovery
New strategies are required to reduce the worldwide burden of tuberculosis. Intracellular survival and replication of Mycobacterium tuberculosis after macrophage phagocytosis is a fundamental step in the complex host-pathogen interactions that lead to granuloma formation and disease. Greater underst...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 
2022-01-14 | E-MTAB-11107 | biostudies-arrayexpress
TranscriptomicsThree-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance
Mycobacteria naturally grow as corded biofilms in liquid media without detergent. Such detergent-free biofilm phenotypes may reflect the growth pattern of bacilli in tuberculous lung lesions. New strategies are required to treat tuberculosis that is responsible for more deaths each year than any oth...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 
2021-01-29 | E-MTAB-9904 | biostudies-arrayexpress
TranscriptomicsDosR-regulon genes induction in Mycobacterium bovis BCG under aerobic conditions
In this report we demonstrated that under aerobic conditions, Mycobacterium bovis BCG expressing an hsp60-driven second copy of the hypoxia-related transcriptional regulator DosR increased 2-fold or greater the expression of 38 out of the 48 genes belonging to the DosR regulon, including the latency...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-20 | E-GEOD-21932 | biostudies-arrayexpress
MetabolomicsUntargeted LC-MS metabolomics of RANKL-differentiated Bone Marrow–Derived Macrophages ± Bacillus Calmette–Guérin (BCG) exposure

To investigate the metabolites and pathways modulated by BCG in RANKL-differentiated macrophages, thereby elucidating the metabolic mechanisms underlying BCG-induced macrophage activation, BMMs were stimulated with 50 ng/mL RANKL for 5 days to generate osteoclast-like cells. Subsequently, one gro...

2026-03-31 | MTBLS12992 | MetaboLights
TranscriptomicsTranscriptome analysis of the Tap efflux pump mutant in Mycobacterium bovis BCG.
We used DNA microarrays to define the physiological roles of the Tap efflux pump in M. bovis BCG during the exponential and the stationary phase of in vitro growth. For this purpose we constructed a M. bovis BCG strain in which the tap gene was inactivated by the insertion of a hygromycin resistance...
ORGANISM(S): Mycobacterium bovis BCG 
2011-12-30 | E-GEOD-32249 | biostudies-arrayexpress
ProteomicsExploring the potential role of moonlighting function of the surface-associated proteins from Mycobacterium bovis BCG Moreau and Pasteur by comparative proteomic
Tuberculosis (TB) is one of major causes of death worldwide. Bacillus Calmette-Guerin (BCG) is the only licensed TB vaccine and its inability to protect against adult pulmonary TB can be due to genetic differences among strains described since the 1940s. In this work, we compared the proteomic profi...
ORGANISM(S): Mycobacterium bovis BCG str. Moreau RDJ 
2019-05-15 | PXD006141 | Pride
Moonlighting function Surface-associated proteins Mycobacterium bovis bcg moreau 
TranscriptomicsKey hub and bottleneck genes differentiate the macrophage response to virulent and attenuated Mycobacterium bovis
Mycobacterium bovis is an intracellular pathogen that causes tuberculosis in cattle. Following infection, the pathogen resides and persists inside host macrophages by subverting host immune responses via a diverse range of mechanisms. Here, a high-density bovine microarray platform was used to exami...
ORGANISM(S): Bos taurus 
2014-08-01 | E-GEOD-59774 | biostudies-arrayexpress
TranscriptomicsComparison of M. tuberculosis and M. bovis BCG in diluted whole blood cultures
Despite wide scale vaccination with Mycobacterium bovis BCG, the prevalence of tuberculosis remains high, reflecting the global variable efficacy of this vaccine against adult pulmonary TB. Characterisation of different immune responses to M. tuberculosis and M. bovis BCG would increase understandi...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-45386 | biostudies-arrayexpress
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