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TranscriptomicsWT vs c-Maf KO fetal liver macrophage
Homozygous disruption of c-Maf led to embryonic lethality and impaired erythroblastic island formation. c-Maf is expressed in the fetal liver macrophages. It suggests that macrophages are responsible for the lethality of c-Maf knock-out embryos. To search downstream genes of c-Maf, we surveyed genes...
ORGANISM(S): Mus musculus 
2011-07-06 | E-GEOD-23305 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild type and MafB/c-Maf double knock out bone marrow cells differentiated into macrophages by culture
MafB and c-Maf deficient (Maf-DKO) or wt bone marrow cells were differentiated into macrophages by culture in DMEM/10%FCS supplemented with 20% M-CSF containing L-929 cell conditioned IMDM/0.5%FCS medium (LCM) with a half medium change on day 5 and then full medium changes every 4 days thereafter. ...
ORGANISM(S): Mus musculus 
2009-11-06 | E-MEXP-2419 | biostudies-arrayexpress
TranscriptomicsMaf-S Knockdown Anopheles gambiae: Tiassale
Transcription factor Maf-S knockdown by dsRNA injection and compared to dsRNA-GFP injected control. Maf-S knockdown was performed to study the affect of xenobiotic stress of the cnc-keap1 pathway.
ORGANISM(S): Anopheles gambiae 
2017-03-19 | E-MTAB-4042 | biostudies-arrayexpress
TranscriptomicsGene array for identifying molecules involved in IL-10 regulation during Th17 polarization
IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 and T-bet double deficient Th17 cells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TGFbeta, and associated with Th17 IL-10 pr...
ORGANISM(S): Mus musculus 
2009-03-03 | E-GEOD-15029 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lymphatic endothelial cells infected with Kaposi's sacoma associated herpes virus
This SuperSeries is composed of the following subset Series: GSE16353: The profile of cellular and KSHV microRNAs in AIDS_KS biopsies (and normal skin control biopsies) GSE16354: Infection of Lymphatic and Blood Vessel Endothelial Cells (LEC and BEC) with KSHV GSE16355: Lymphatic endothelial cells (...
ORGANISM(S): Homo sapiens 
2009-09-30 | E-GEOD-16357 | biostudies-arrayexpress
TranscriptomicsGene expression profiles from cultured skin fibroblasts of two MAF mutation-positive subjects
Total RNA was obtained from cultured skin fibroblasts of two MAF mutation-positive subjects and control (dermal adult skin fibroblasts, ATCC PCS-201-012) (each in duplicates), and was subjected for gene expression profiling to identify differentially expressed genes (DEG).
ORGANISM(S): Homo sapiens 
2015-07-31 | E-MTAB-3250 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of MafF-/-: MafG-/-: MafK-/- embryos and MafF-/-: MafG+/+: MafK-/- embyos
MafF-/-: MafG+/+: MafK-/- mice are viable, while MafF-/-: MafG-/-: MafK-/- mice are embryonic lethal. To get an insight into the cause of the lethality of small Maf triple knockout mice, transcriptome analysis was performed using whole embyos of MafF-/-: MafG-/-: MafK-/- at E10.5 and those of MafF-...
ORGANISM(S): Mus musculus 
2012-01-09 | E-GEOD-29558 | biostudies-arrayexpress
ProteomicsThe deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival
USP7, as a deubiquitination enzyme, controls ubiquitination and stability of Maf family proteins. USP7 promotes Maf transcriptional activity. Moreover, USP7 is overexpressed in multiple myeloma cells and its expression level is negatively correlated to the survival of myeloma patients.
ORGANISM(S): Homo sapiens (Human) 
2019-12-16 | PXD016020 | Pride
Usp7 Myeloma Deubiquitinase Maf 
TranscriptomicsEffect of c-Maf mutation on Mafb-GFP-positive FACS-purified cells in the E12.5 mouse gonad
Morphogenesis of the gonad requires cell-cell adhesion changes between diverse cell types. In the Drosophila gonad, the gene traffic jam regulates cell adhesion changes required for gonad formation and germ cell development (Li et al., 2003. Nature Cell Biol). To determine if the mammalian homologs ...
ORGANISM(S): Mus musculus 
2013-11-20 | E-GEOD-41715 | biostudies-arrayexpress
ProteomicsIntestinal epithelial c-Maf expression determines enterocyte differentiation and nutrient uptake
The primary function of the small intestine (SI) is to absorb nutrients to maintain whole body energy homeostasis. Enterocytes are the major epithelial cell type facilitating nutrient sensing and uptake. However, the molecular regulators governing enterocytes have remained undefined. In this project...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-08 | PXD034829 | Pride
Enterocytes Transcriptional regulation Differentiation C-maf Nutrient uptake 
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