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ProteomicsRayo et al Immunoediting Role for Major Vault Protein in Apoptotic Signaling Induced by N-Acyl Homoserine Lactones
In order to find investigate the immunomodulatory effects of the bacterial signaling molecule N-(3-Oxododecanoyl)-L-homoserine lactone, a synthetic analogue was prepared in order to identify potential mammalian receptors. SILAC-labeled normal human bronchial epithelial (NHBE) cells were used. Additi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-18 | MSV000084474 | MassIVE
ProteomicsExploring the vault interactome in the divergent eukaryote Trypanosoma brucei
Many, but not all Eukaryotes have protein-enclosed compartments called vaults. Vaults are composed of multiple copies of the major vault protein (MVP), symmetrically assembled into a basket like shell. Whilst there is some evidence that these compartments are engaging in mRNA maturation and intrigui...
ORGANISM(S): Trypanosoma brucei 
2024-12-12 | PXD056004 | Pride
Trypanosoma Affinity isolation Major vault protein Cryomilling Bioid Vault particle 
ProteomicsProteomics of extracellular cement material in the Atlantic salmon louse
Major vault protein (MVP) is the main component of the vault complex, which is a highly conserved ribonucleoprotein complex found in most eukaryotic organisms. MVP or vaults have previously been found to be overexpressed in multidrug-resistant cancer cells and implicated in various cellular processe...
ORGANISM(S): Lepeophtheirus salmonis salmonis 
2024-08-10 | PXD050812 | Pride
Salmon louse Cement Major vault protein 
UnknownThe trypanosome vault particle is composed of multiple major vault protein paralogs and harbors vault RNA.
Not available
S-EPMC12547018 | biostudies-literature
UnknownMajor vault protein regulates cell growth/survival signaling through oxidative modifications.
Not available
S-EPMC4679458 | biostudies-literature
GenomicsDissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein
Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein
PRJNA1017498 | ENA
ProteomicsSingle-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance
Recently developed covalent inhibitors for RasG12C provide the first pharmacological tools to target mutant Ras-driven cancers. However, the rapid development of resistance to current clinical Ras G12C inhibitors is common. Presumably, a subpopulation of RasG12C-expressing cells adapt their signalin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-16 | MSV000094779 | MassIVE
ProteomicsVault Interactome in WT and PARP4-Depleted A549 Cells
We sought to determine whether the vault complex component Poly (ADP-ribose) Polymerase 4 (PARP4) would impact the identity or relative enrichment of proteins that interacted with the vault. We conducted co-immunoprecipitation (co-IP) experiments targeting the human major vault protein (MVP) using a...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD052802 | Pride
Lung non-small cell carcinoma Parp4 Human Mvp A549 Alveolar basal epithelial cells Vault 
UnknownSelection and characterisation of a phage-displayed human antibody (Fab) reactive to the lung resistance-related major vault protein.
Not available
S-EPMC2364164 | biostudies-literature
TranscriptomicsDissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein
Using mouse genetic studies and systematic assessments of brain neuroanatomical phenotypes, we set out to identify which of the 30 genes causes brain defects at the autism-associated 16p11.2 locus. We show that multiple genes mapping to this region interact to regulate brain anatomy, with female mic...
ORGANISM(S): Mus musculus 
2023-09-15 | GSE243261 | GEO
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