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TranscriptomicsNSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [iCLIP]
Autosomal-recessive loss of the NSUN2 gene has been recently identified as a causative link to intellectual disability disorders in humans. NSun2 is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNA). Whether NSun2 methylates additional RNA species is currently debated. Here, we a...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-44385 | biostudies-arrayexpress
TranscriptomicsNSun2-mediated cytosine-5 methylation in Vault non-coding RNA determines its processing into small RNAs [RNA-seq]
Autosomal-recessive loss of the NSUN2 gene has been recently identified as a causative link to intellectual disability disorders in humans. NSun2 is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNA). Whether NSun2 methylates additional RNA species is currently debated. Here, we a...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-44384 | biostudies-arrayexpress
TranscriptomicsThe non-coding RNA of the multidrug resistance-linked vault particle encodes multiple regulatory small RNAs
Vault particles are conserved organelles that have been implicated in multidrug resistance and intracellular transport. They are formed by three different proteins and the non-coding vault RNAs (vRNAs). Here we show that human vRNAs produce several small RNAs (svRNAs) by mechanisms different from th...
ORGANISM(S): Homo sapiens 
2009-09-07 | E-GEOD-16060 | biostudies-arrayexpress
Genomics
Microbiota Vault
PRJEB102395 | ENA
ProteomicsVault Interactome in WT and PARP4-Depleted A549 Cells
We sought to determine whether the vault complex component Poly (ADP-ribose) Polymerase 4 (PARP4) would impact the identity or relative enrichment of proteins that interacted with the vault. We conducted co-immunoprecipitation (co-IP) experiments targeting the human major vault protein (MVP) using a...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD052802 | Pride
Lung non-small cell carcinoma Parp4 Human Mvp A549 Alveolar basal epithelial cells Vault 
ProteomicsExploring the vault interactome in the divergent eukaryote Trypanosoma brucei
Many, but not all Eukaryotes have protein-enclosed compartments called vaults. Vaults are composed of multiple copies of the major vault protein (MVP), symmetrically assembled into a basket like shell. Whilst there is some evidence that these compartments are engaging in mRNA maturation and intrigui...
ORGANISM(S): Trypanosoma brucei 
2024-12-12 | PXD056004 | Pride
Trypanosoma Affinity isolation Major vault protein Cryomilling Bioid Vault particle 
UnknownThe trypanosome vault particle is composed of multiple major vault protein paralogs and harbors vault RNA.
Not available
S-EPMC12547018 | biostudies-literature
UnknownThe Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.
Not available
S-EPMC2193651 | biostudies-literature
GenomicsMicrobial inoculation of yedoma permafrost incubations, Vault permafrost tunnel, Alaska
Vault permafrost tunnel, Alaska, inoculation study
PRJEB51405 | ENA
ProteomicsThe vault associates with membranes in situ
The eukaryotic vault particle is a giant ribonucleoprotein complex that assembles into an iconic barrel-like cage. Its cellular function has remained elusive despite extensive characterization. Using cryo-electron tomography of Dictyostelium discoideum cells, we define the distribution, structural s...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2026-04-21 | PXD071329 | Pride
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