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TranscriptomicsDifferentiation of Mammary Tumors and Reduction in Metastasis Upon Malat1 LncRNA Loss
Genome-wide analyses have identified thousands of long non-coding RNAs (lncRNAs). Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is among the most abundant lncRNAs whose expression is altered in numerous cancers. Here we report that genomic loss, as well as systemic knockdown of Mal...
ORGANISM(S): Mus musculus 
2016-01-12 | E-GEOD-67647 | biostudies-arrayexpress
TranscriptomicsLong Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB
The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism is poorly understood. We demonstrate that MALAT1 levels are regulated during normal cell cycle progression. Genome-wide transcriptome analys...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-44240 | biostudies-arrayexpress
ProteomicslncRNA MALAT1 interactome - Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that was first discovered as a prognostic marker for lung cancer metastasis. MALAT1 has been implicated in the tumorigenesis of numerous tumor types. To further delineate the underlying molecular mechan...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD005154 | Pride
Rna pulldown Malat1 Lncrna Lc-ms/ms 
TranscriptomicsThe Nuclear-retained non-coding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation
Alternative splicing (AS) of pre-mRNA is utilized by higher eukaryotes to achieve increased transcriptome and proteomic complexity. The serine/arginine (SR) splicing factors regulate tissue- or cell type-specific AS in a concentration and phosphorylation dependent manner. However, the mechanisms tha...
ORGANISM(S): Homo sapiens 
2010-09-01 | E-GEOD-22963 | biostudies-arrayexpress
ProteomicsQuantitative Proteomics to identify nuclear RNA-binding proteins of Malat1
The long non-coding RNA Malat1 has been implicated in several human cancers, while the mechanism of action is not completely understood. As RNAs in cells function in the context of RBPs identification of their RNA-binding proteins can shed light on their functionality. We here performed quantitative...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-29 | PXD017309 | Pride
Malat1  lncrna  rbps  interactome 
GenomicsThe long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites
Long noncoding RNAs (lncRNAs) are important regulators of chromatin; however, the mechanistic roles for many lncRNAs are poorly understood in part because their direct interactions with genomic loci and proteins are difficult to assess. We used CHART-seq to map the genomic binding sites for two high...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-58444 | biostudies-arrayexpress
TranscriptomicsEffects of the long noncoding RNA Malat1 on gene expression [Mouse430_2]
Malat1 is an abundant long noncoding RNA that localizes to nuclear bodies known as nuclear speckles, which contain a distinct set of pre-mRNA processing factors. Previous in vitro studies have demonstrated that Malat1 interacts with pre-mRNA splicing factors, including the serine- and arginine-rich ...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-37705 | biostudies-arrayexpress
TranscriptomicsEffects of the long noncoding RNA Malat1 on gene expression [MoEx-1_0-st]
Malat1 is an abundant long noncoding RNA that localizes to nuclear bodies known as nuclear speckles, which contain a distinct set of pre-mRNA processing factors. Previous in vitro studies have demonstrated that Malat1 interacts with pre-mRNA splicing factors, including the serine- and arginine-rich ...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-37706 | biostudies-arrayexpress
TranscriptomicsEffects of the long noncoding RNA Malat1 on gene expression
This SuperSeries is composed of the following subset Series: GSE37705: Effects of the long noncoding RNA Malat1 on gene expression [Mouse430_2] GSE37706: Effects of the long noncoding RNA Malat1 on gene expression [MoEx-1_0-st] Refer to individual Series
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-37707 | biostudies-arrayexpress
ProteomicsAlternative splicing modulation mediated by G-quadruplex structures in MALAT1 lncRNA
MALAT1, an abundant lncRNA specifically localized to nuclear speckles, regulates alternative-splicing (AS). The molecular basis of its role in AS remains poorly understood. Here, we report three conserved, thermodynamically stable, parallel RNA-G-quadruplexes (rG4s) present in the 3’ region of MALAT...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026386 | Pride
Lncrna Alternative splicing G-quadruplex Malat1 Nucleolin 
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