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ProteomicsTrazodone is neuroprotective via rescue of dysregulated synaptic and mitochondrial translatomes in neurodegeneration
We aime to discover changes which occur at the hippocampal nascent proteome prion to the neurodegeneration characteristic of prion disease and how this prion signature difer from that of proven neuroprotective drug trazodone hydrochloride. To label the nacent proteome we used non-canonical aminoacid...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042577 | Pride
Synapse Upr/isr Trazodone Neurodegeneration Translational repression Mutochondria Translatome 
TranscriptomicsTranslational profiling of HEK293 cells exposed to cold shock (32 degrees C) and untreated (37 degrees C)
This experiment investigates the effect of mild cold-shock (32 degrees C, 24 hours) on the translatome of human HEK293 cells. After cold-shock, cells were treated with cycloheximide to block elongation, then sucrose density gradients were used to separate post-nuclear extracts into polysome and subp...
ORGANISM(S): Homo sapiens 
2017-02-23 | E-MTAB-5437 | biostudies-arrayexpress
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