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ProteomicsTrazodone is neuroprotective via rescue of dysregulated synaptic and mitochondrial translatomes in neurodegeneration
We aime to discover changes which occur at the hippocampal nascent proteome prion to the neurodegeneration characteristic of prion disease and how this prion signature difer from that of proven neuroprotective drug trazodone hydrochloride. To label the nacent proteome we used non-canonical aminoacid...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042577 | Pride
Synapse Upr/isr Trazodone Neurodegeneration Translational repression Mutochondria Translatome 
ProteomicsRepurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology
Drug repurposing offers a cost-effective strategy for accelerating therapeutic development. This study identifies trazodone, an FDA-approved anti-depressant, as a promising therapeutic candidate for Alzheimer’s disease (AD). We show that trazodone use in patients with AD is associated with decreased...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-02 | PXD071776 | Pride
GenomicsRepurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology
Repurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology
PRJNA1390184 | ENA
TranscriptomicsRepurposing Trazodone for Alzheimer's Disease to Modulate Soluble ST2 Levels and Alleviate Alzheimer's Pathology
Alzheimer’s disease (AD) is a multifactorial disorder involving various pathological mechanisms, such as amyloidosis, immune dysfunctions and synaptic impairments, which are important therapeutic targets. Repurposing drugs to target these mechanisms offers a promising approach to reduce the costs an...
ORGANISM(S): Mus musculus 
2026-07-01 | GSE314159 | GEO
GenomicsIntegrative Transcriptomics Identifies Trazodone as a Modulator of Urban Particulate Matter-Induced Neuroinflammation
Integrative Transcriptomics Identifies Trazodone as a Modulator of Urban Particulate Matter-Induced Neuroinflammation
PRJNA1482153 | ENA
UnknownNew Pharmaceutical Salts of Trazodone.
Not available
S-EPMC7867375 | biostudies-literature
TranscriptomicsIntegrative Transcriptomics Identifies Trazodone as a Modulator of Urban Particulate Matter-Induced Neuroinflammation
Urban particulate matter (UPM) triggers neuroinflammation through microglial activation, contributing to the progression of neurodegenerative diseases; however, effective therapeutic interventions remain limited. In this study, we investigated the inhibitory effects of trazodone (TZ), a clinically a...
ORGANISM(S): Mus musculus 
2026-06-30 | GSE336648 | GEO
UnknownEstimation of an Appropriate Dose of Trazodone for Pediatric Insomnia and the Potential for a Trazodone-Atomoxetine Interaction.
Not available
S-EPMC7020267 | biostudies-literature
UnknownCharacterization of trazodone metabolic pathways and species-specific profiles.
Not available
S-EPMC12518996 | biostudies-literature
UnknownTrazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder.
Not available
S-EPMC11798982 | biostudies-literature
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