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TranscriptomicsT-cell lymphoblastic lymphomas induced by gamma-irradiation
This SuperSeries is composed of the following subset Series: GSE10858: Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas GSE10859: Expression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas GSE10891: Gamma-irradiation induced T-cell lymphomas (miRNA study) Keywor...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10861 | biostudies-arrayexpress
TranscriptomicsExpression profile of BCR-ABL1-transformed, Cdk4 R24C, Cdk6 R31C cell lines
Cdk4 and Cdk6 are two related kinases that bind D-type cyclins and regulate cell cycle progression. Due to their relevance in cancer, Cdk4/6 inhibitors are currently in advanced clinical trials in multiple tumor types. Cdk4/6 are inhibited by INK4 proteins that exert tumor suppressing functions. To ...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-59024 | biostudies-arrayexpress
TranscriptomicsCDK6 as key regulator of hematopoietic and leukemic stem cell activation.
The cyclin-dependent kinases (CDK) CDK6 and CDK4 have redundant functions in regulating cell-cycle progression. We describe a novel role for CDK6 in hematopoietic and leukemic stem cells (HSCs and LSCs) that exceeds its function as cell-cycle regulator. Although hematopoiesis appears regular under s...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-62012 | biostudies-arrayexpress
TranscriptomicsComparative Genomic hybridization of gamma-irradiated T-cell lymphomas
This analysis compares the signal of DNA from T-cell lymphoblastic lymphomas induced by gamma-irradiation versus normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wilf-type tissues, lymphomas and leukemias C57BL/6J animals were maintained in our animal facilities following the a...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10858 | biostudies-arrayexpress
TranscriptomicsExpression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas
This set of data contains the expression levels of cDNAs in T-cell lymphoblastci lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wilf-type tissues, lymphomas and leukemias C57BL/6J animals were mainta...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10859 | biostudies-arrayexpress
TranscriptomicsGamma-irradiation induced T-cell lymphomas (miRNA study)
This set of data contains the expression levels of cDNAs in T-cell lymphoblastic lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wild-type tissues, lymphomas and leukemias C57BL/6J animals were mainta...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-10891 | biostudies-arrayexpress
TranscriptomicsCombinatorial effects of microRNA to suppress the myc oncogenic pathway
Many mammalian transcripts contain target sites for multiple miRNAs, although it is not clear to what extent miRNAs may coordinately regulate single genes. We have mapped the interactions between down-regulated miRNAs and overexpressed target protein-coding genes in murine and human lymphomas. Myc, ...
ORGANISM(S): Homo sapiens 
2012-03-29 | E-GEOD-23026 | biostudies-arrayexpress
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