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ProteomicsCellular interactome of HSV-1 pUL21
The herpes simplex virus (HSV)-1 protein pUL21 is essential for efficient virus replication and dissemination. While pUL21 has been shown to promote multiple steps of virus assembly and spread, the molecular basis of its function remained unclear. Here we identify that pUL21 is a virus-encoded adapt...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD027257 | Pride
Col4a3bp Herpes simplex virus 1 Herpesvirus Protein phosphatase 1 Cert Silac Pp1 
GenomicsMicroRNAs maintain bivalency in mouse embryonic stem cells [ChIP-seq]
The protein Dicer is required for microRNA (miRNA) biogenesis, and therefore Dicer-deficient cells lack all mature, functional miRNAs. Here we investigated the binding of the PRC2 component Ezh2 in wildtype and Dicer-deficient mouse embryonic stem cells genomewide using ChIP-sequencing analysis. Exa...
ORGANISM(S): Mus musculus 
2016-06-02 | E-GEOD-60160 | biostudies-arrayexpress
TranscriptomicsGlobal hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: normal head and neck tissue
Genome-wide DNA methylation profiling of head and neck squamous cell carcinomas. The Illumina Infinium 27k Human DNA methylation BeadChip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in fresh-frozen tumor tissues. Samples included 91 tumors from the oralpharynx a...
ORGANISM(S): Homo sapiens 
2011-10-27 | E-GEOD-25083 | biostudies-arrayexpress
TranscriptomicsGlobal hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: HNSCC
Genome-wide DNA methylation profiling of head and neck squamous cell carcinomas (HNSCCs). The Illumina Infinium 27k Human DNA methylation BeadChip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in fresh-frozen tumor tissues. Samples included 91 tumors from the oral...
ORGANISM(S): Homo sapiens 
2011-10-27 | E-GEOD-25089 | biostudies-arrayexpress
TranscriptomicsGlobal hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: blood controls
Genome-wide DNA methylation profiling of head and neck squamous cell carcinomas (HNSCCs). The Illumina Infinium 27k Human DNA methylation BeadChip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in fresh-frozen tumor tissues. Samples included 91 tumors from the oral...
ORGANISM(S): Homo sapiens 
2011-10-27 | E-GEOD-25091 | biostudies-arrayexpress
TranscriptomicsExpression data from wildtype and Dicer-deficient mouse embryonic stem (ES) cells at different stages of the cell cycle.
The protein Dicer is required for microRNA (miRNA) biogenesis. Dicer-deficient cells therefore lack almost all mature, functional miRNAs. We investigated the role of miRNAs in regulation of gene expression in mouse ES cells by analysing gene expression in either wildtype or Dicer-deficient cells gro...
ORGANISM(S): Mus musculus 
2016-06-02 | E-GEOD-60096 | biostudies-arrayexpress
UnknownThe structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster.
Not available
S-EPMC4259220 | biostudies-literature
ProteomicsTHEM6-mediated lipid remodelling sustains stress resistance in cancer (Part1 : AP-MS)
Despite the clinical benefit of androgen-deprivation therapy (ADT), the majority of patients with advanced prostate cancer (PCa) ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we identified thioesterase superfamily member 6 (THEM6) as a marker of ADT resistance...
ORGANISM(S): Homo sapiens (Human) 
2021-12-11 | PXD024407 | Pride
Castration-resistant prostate cancer Cancer metabolism Endoplasmic reticulum Cancer proteomics 
GenomicsMicroRNAs maintain bivalency in mouse embryonic stem cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-06-02 | E-GEOD-60161 | biostudies-arrayexpress
ProteomicsFederated deep learning enables cancer subtyping by proteomics
Artificial intelligence (AI) applications in biomedical settings face challenges such as data privacy and regulatory compliance. Federated Deep Learning (FDL) effectively addresses these issues. We developed ProCanFDL, where local models were trained on simulated sites using proteomic data drawn fro...
ORGANISM(S): Homo sapiens (Human) 
2025-05-29 | PXD056810 | Pride
Procanfdl Pan-cancer Human Swath-ms Proteomics Federated deep learning 
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